Gu Xiaowu

Caveolins and caveolae in ocular physiology and pathophysiology.

Herein, we provide the first comprehensive review of literature on caveolae, caveolins, and other membrane domains in the context of visual system function.

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia.

Our results suggest that hyperactive eNOS signaling in the CO pathway of both Cav1ΔEC and global Cav1 knockout mice results in chronic dilation of distal CO vessels and protein nitration, but that Cav1 expression in…

Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection.

Microglial activation is secondary to axonal injury and plays a bystander role in the ONC model.