Gudiseva Harini V

Characterizing the "POAGome": A bioinformatics-driven approach to primary open-angle glaucoma.

We propose a molecular model of POAG revolving around TGF-β signaling, which incorporates the roles of inflammation and senescence in this disease. Finally, we highlight emerging molecular therapies that show promise for treating POAG.

The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans.

In sum, the POAAGG study population is very admixed, with a higher degree of African ancestry associated with an increased POAG risk.

The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.

The V83I polymorphism was associated strongly with POAG in AA men and disrupts Aβ-binding to CO1. This region also interacts with a neuroprotective protein, UBQLN1.

Prevalence and Factors Associated with Optic Disc Tilt in the Primary Open-Angle African American Glaucoma Genetics Study.

There are substantial numbers of tilted optic discs in glaucoma patients with African ancestry. They occur more frequently in female subjects and younger subjects and are associated with several ocular features but not with myopia.

The primary open-angle african american glaucoma genetics study: baseline demographics.

The POAAGG study has currently recruited more than 2000 African Americans eligible for a POAG genetics study.