Ha Ahnul

Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-analysis.

For each unit (1-D) increase in myopia, the risk of glaucoma increases by approximately 20%. The risk more steeply increases in high-degree myopia, representing a significant nonlinear relationship.

Temporal Relation between Macular Ganglion Cell-Inner Plexiform Layer Loss and Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma.

In eyes with early glaucoma, mGCIPL change is frequently detected before corresponding pRNFL change.

Explaining the Rationale of Deep Learning Glaucoma Decisions with Adversarial Examples.

Adversarial explanation increased the explainability over GradCAM, a conventional heatmap-based explanation method. Adversarial explanation may help medical professionals understand more clearly the rationale of DLMs when using them for clinical decisions.

Baseline Lamina Cribrosa Curvature and Subsequent Visual Field Progression Rate in Primary Open-Angle Glaucoma.

The baseline maLCCI showed a significant correlation with the rate of subsequent VF deterioration.

Temporal Raphe Sign for Discrimination of Glaucoma from Optic Neuropathy in Eyes with Macular Ganglion Cell-Inner Plexiform Layer Thinning.

In clinical practice, determining whether the temporal raphe sign appears on OCT macular scans can be a useful tool for discrimination of glaucomatous from nonglaucomatous mGCIPL thinning.

Combined Use of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Event-based Progression Analysis.

The various progression patterns were confirmed according to the locations and baseline patterns of glaucomatous structural change on the integrated GPA map (GPA PanoMap).

Ten Years and Beyond Longitudinal Change of ß-Zone Parapapillary Atrophy: Comparison of Primary Open-Angle Glaucoma with Normal Eyes.

The pattern of ß-zone PPA change differed between POAG and normal eyes during a follow-up of 10 years or more.

Twenty-four-Hour Intraocular Pressure-Related Patterns from Contact Lens Sensors in Normal-Tension Glaucoma and Healthy Eyes: The Exploring Nyctohemeral Intraocular pressure related pattern for Glaucoma Management (ENIGMA) Study.

Continuous monitoring of 24-hour IOP-related values with CLS can be useful for assessment of glaucoma risk, especially for patients with NTG whose IOP appears to be in the normal range.

Ellipsoid Zone Change According to Glaucoma Stage Advancement.

According to SD-OCT, relative EZ intensity reduction occurs in the mild-to-moderate and severe glaucoma stages.

Pre-perimetric Open Angle Glaucoma with Young Age of Onset: Natural Clinical Course and Risk Factors for Progression.

In untreated pre-perimetric OAG patients with a "young age of onset" condition, the estimated MD slope for the disease course of more than 5 years was -0.03 dB/y, and the average RNFL thinning rate was -0.46 μm/y.

Facial Port-Wine Stain Phenotypes Associated with Glaucoma Risk in Neonates.

Among the newborns with facial PWS, 1) a greater extent of birthmarks involving the S2 area, and 2) lesions including the lower eyelid were associated with higher risk of glaucoma development within the neonatal period.

Interventions for Glaucoma Medication Adherence Improvement: A Network Meta-analysis of Randomized Controlled Trials.

The NMA indicated that tailored care can improve adherence to glaucoma medication compared with SOC. A multifaceted approach might yield additional improvements.

Incidence of Sturge-Weber Syndrome and Risk of Secondary Glaucoma: A Nationwide Population-based Study Using a Rare Disease Registry.

This study identified birth-cohort SWS incidence and determined secondary-glaucoma risk in a population of East Asian ethnicity. These data could help to promote better understanding of the epidemiologic features of SWS patients.

Association of Optic Disc Tilt and Torsion with Open-Angle Glaucoma Progression Risk: Meta-Analysis and Meta-Regression Analysis.

Evidence for the effects of optic nerve deformation on glaucoma progression is still lacking. Future research using stratified analysis according to age and tailored diagnostic criteria will allow for more rigorous analyses for this topic.

Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study.

Sovesudil 0.25% and 0.5% TID showed statistically significant IOP-lowering effects and 0.5% concentration's IOP-lowering effects met the superiority criteria in comparison with the placebo at week 4.

Decision Tree Algorithm-Based Prediction of Vulnerability to Depressive and Anxiety Symptoms in Caregivers of Children With Glaucoma.

Evaluation of the number of glaucoma surgeries and VA in the better eye can be a useful decision support tool in predicting mental illness in caregivers of children with glaucoma.

Association of Angle Width With Progression of Normal-Tension Glaucoma: A Minimum 7-Year Follow-up Study.

Narrow-angle NTG showed a greater probability of disease progression than did wide-angle NTG. Further studies determining whether augmented or differentiated treatment strategies would be beneficial for patients with narrow-angle NTG are warranted.

Association between Sight-Threatening Eye Diseases and Death by Suicide in South Korea: A Nationwide Population-based Cohort Study.

In South Korea between 2010 and 2020, a higher suicide rate was evident among those with diagnosed STED than for persons not so diagnosed.

Temporal Raphe Sign in Elderly Patients With Large Optic Disc Cupping: Its Evaluation as a Predictive Factor for Glaucoma Conversion.

In elderly subjects with large CDR, temporal raphe sign positivity on the baseline macular GCIPL thickness map was associated with faster conversion to NTG.

Measurement of Optic Disc Cup Surface Depth Using Cirrus HD-OCT.

In early-to-moderate glaucoma, the cup surface depth changed faster than did the RNFL thickness.

Placebo Effect and Its Determinants in Ocular Hypotensive Therapy: Meta-analysis and Multiple Meta-regression Analysis.

The placebo effect has been studied and documented within a wide clinical context. It remains unclear whether placebo is effective in glaucoma treatment or, if so, which factors are determinative of effect size (ES).

Macular sector-wise decision tree model for the prediction of parafoveal scotoma not detected by 24-2 visual field test.

In clinical practice, the evaluation of the 24-2 perifoveal test points along with the probability colour codes of mGCIPL can be a useful decision-support tool in determining whether 10-2 tests are needed for a given…

Interdigitation Zone Change According to Glaucoma-Stage Advancement.

SD-OCT revealed a reduction in IZ area in NTG eyes, and the extent of the reduction was positively associated with glaucoma severity.

Effects of nicotinamide supplementation in normal-tension glaucoma: a crossover placebo-controlled randomised clinical trial.

Oral NAM supplementation in NTG participants induced functional improvement, as measured by PhNRPT and B-wave amplitude.

Nationwide Incidence of Infantile Cataract Surgery and Risk of Secondary Glaucoma in a Population-based Birth Cohort.

This study identified the birth cohort incidence of IC surgery and secondary glaucoma risk in individuals of East Asian ethnicity.

Association of Intereye Visual-Sensitivity Asymmetry With Progression of Primary Open-Angle Glaucoma.

Among POAG eyes with comparable hemifield VFDs, eyes without a corresponding hemifield defect in the fellow eye showed faster rates of progression compared with those with a corresponding hemifield defect.

Optic Disc Microhemorrhage in Primary Open-Angle Glaucoma: Clinical Implications for Visual Field Progression.

Micro-DH was found prior to macro-DH detection in a significant proportion of POAG patients; micro-DH, moreover, was associated with earlier and faster VF progression.

SMOTE-Enhanced Explainable Artificial Intelligence Model for Predicting Visual Field Progression in Myopic Normal Tension Glaucoma.

The SMOTE-enhanced AI model shows reasonable predictive performance and potential clinical utility for identifying visual field progression in myopic NTG patients, though further validation in larger cohorts is needed.

Predicting the Therapeutic Efficacy of Laser Peripheral Iridotomy for Individuals With Asymptomatic Narrow Angle: The Triple Hump Sign.

PACS eyes indicating the positive-TH sign showed, at post-LPI 1 month, a greater IOP decrease.

Valsalva Maneuver-induced Changes in Anterior Lamina Cribrosa Surface DEPTH: A Comparison Between Normal and Glaucomatous Eyes.

During the VM, the ALCSD was decreased in normal eyes, but was not significantly changed in eyes with treated glaucoma.

Incidence of and Risk Factors for Fellow-Eye Involvement in Sturge-Weber Syndrome Children With Unilateral Glaucoma.

In this cohort of SWS children diagnosed with unilateral glaucoma, the risk of fellow-eye involvement was higher in girls, within the first 4 years, and in cases with choroidal hemangioma.

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Conversion of Single Optic Disc Photography into 3-Dimensional Image.

Corrigendum to "Association Between Alpha-Blockers for Benign Prostatic Hyperplasia and Acute Angle-Closure Glaucoma". Am J Ophthalmol. 2026;282:197-205.

Association Between Alpha-Blockers for Benign Prostatic Hyperplasia and Acute Angle-Closure Glaucoma.

This study demonstrates a significant, duration-dependent association between α-blocker use for BPH and an increased risk of AACG.

Synergistic effects of glaucoma, degeneration of macula and posterior pole, and diabetic ophthalmic complications on vision loss.

The presence of multiple ARODs significantly elevates the risk of severe VI. These findings emphasise the need for integrated eye care, including prevention of developing additional ARODs.

Clinical Significance of Optic Disc Hemorrhage Size in Visual Field Progression in Glaucoma.

DH size was associated with the rate of VF deterioration. Eyes with larger DH showed more pronounced VF progression.

Trends in Childhood Glaucoma Prevalence and Incidence in South Korea, 2002-2019: A Nationwide Population-Based Study.

This study identified childhood glaucoma prevalence and incidence in a general population of East Asian ethnicity.

Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects.

DL models, trained with both fundus images and clinical data, showed the potential to predict whether and when normotensive GS patients will show conversion to NTG.