Hammond Christopher J

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population.

In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT.

Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations.

The significance of this finding is that higher numbers of healthy individuals in the population are expected to be carriers of this mutation, which in turn reduces the utility of identifying carriers of this mutation…

Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort.

Ganglion cell complex thickness appears to be highly heritable and further genetic analysis may help identify new biological pathways for glaucoma.

Genetic Heritability of Pigmentary Glaucoma and Associations With Other Eye Phenotypes.

These findings support the conclusion that pigmentary glaucoma may have a genetic basis and be highly heritable.

Genetic African Ancestry Is Associated With Central Corneal Thickness and Intraocular Pressure in Primary Open-Angle Glaucoma.

This study demonstrated that a higher proportion of GAA was associated with a thinner CCT and a higher IOP in POAG patients.

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.

These analyses suggest that there is limited genetic correlation between diabetes- and glaucoma-related traits.

Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development.

Common SNPs relating to the GSAP and GRM5/TYR genes are associated risk factors for the development of PDS and PG.

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects.

In this study, we report the results of genomewide levels of association of three loci on chromosome X with IOP, and provide a framework to include chromosome X in large-scale genomewide association analyses for complex…

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses.

We have built a structured ocular transcriptomics library to estimate cell line enrichment among association signals from genome-wide association studies that may be extended by incorporating other datasets.