Han Xikun

An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity.

The IOP PRS was correlated positively with maximum IOP, disease severity, need for surgery, and number of affected family members.

Myocilin Gene Gln368Ter Variant Penetrance and Association With Glaucoma in Population-Based and Registry-Based Studies.

The MYOC p.Gln368Ter variant confers a very high-risk effect size for advanced glaucoma; the risk is lower in nonadvanced glaucoma and OHT.

Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration.

Our findings improve the knowledge of the genetic architecture of AMD and help achieve better accuracy in AMD prediction.

Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma.

In this study, high polygenic risk was associated with more rapid structural and functional progression in early POAG, despite more intensive treatment.

Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging.

These findings support the use of multitrait modeling of corneal parameters in a relatively large data set to identify new keratoconus risk loci and enhance polygenic risk score models.

Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review.

Advances in glaucoma genetics have opened the door for risk stratification based on genetic risk predictions.

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.

Monogenic and high polygenic risk were each associated with a more than 2.5-fold increased odds of developing glaucoma and an equivalent mean age at glaucoma diagnosis, with high polygenic risk more than 15 times more…

High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma.

This study demonstrated novel associations between glaucoma polygenic risk and risk of commencement or escalation of IOP-lowering therapy, building on previous work highlighting the potential clinical usefulness of genetic risk stratification in glaucoma.

A Polygenic Risk Score Predicts Intraocular Pressure Readings Outside Office Hours and Early Morning Spikes as Measured by Home Tonometry.

A validated IOP PRS was associated with higher early morning IOP and mean IOP outside office hours.

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

We found little genetic evidence supporting a causal association between SA and glaucoma.

High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.

This report identified clinically relevant correlations between glaucoma PRS and the need for surgical intervention in patients with glaucoma.

Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.

VCDR and IOP PRSs derived using a large recently published multitrait GWAS exhibited validity across independent cohorts.