Harris Alon

Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research.

Herein, the authors discuss the theory of operation for optical coherence tomography angiography and the current findings from pilot studies with a focus on open-angle glaucoma.

Ocular blood flow as a clinical observation: Value, limitations and data analysis.

This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while…

The effects of antioxidants on ocular blood flow in patients with glaucoma.

One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.

Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review.

In contrast, although testosterone may have known effects in the cardiovascular and cerebrovascular systems, there is no consensus as to its effects in ocular health or POAG.

Targeting Transforming Growth Factor-β Signaling in Primary Open-Angle Glaucoma.

The purpose of this review is to discuss possible therapeutic strategies targeting TGF-β in the treatment of POAG.

Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years.

In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years.

Circadian Rhythm and Glaucoma: What do We Know?

Glaucoma progression is influenced by multiple physiological factors regulated by the circadian rhythm.

Overdiagnosis of open-angle glaucoma in the general population: the Thessaloniki Eye Study.

The overdiagnosis of OAG was substantial in this elderly, Caucasian population. The overdiagnosis of glaucoma has not been previously addressed in population-based studies and needs to be further explored.

The Influence of Translaminar Pressure Gradient and Intracranial Pressure in Glaucoma: A Review.

We find that while low ICP is associated with glaucoma disease in most studies, evidence is mixed on how closely ICP matches retrolaminar tissue pressure, and it appears the relationship is affected by the size…

Ocular hypotensive effect of the novel EP3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study.

Subjects randomised to receive ONO-9054 were more likely to achieve a greater per cent reduction in IOP and were more likely to achieve target IOPs than those receiving Xalatan.

Factors Associated With Retinal Vessel Diameters in an Elderly Population: the Thessaloniki Eye Study.

Our study confirms previous reports about the association of age and BP with vessel diameters.

Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?

Whole image vessel density is also significantly decreased in glaucoma patients compared with controls, and this outcome has been found to correspond to severity of visual field loss.

Retinal oximetry in glaucoma: investigations and findings reviewed.

This review surveys the research on retinal metabolism in POAG using spectroscopic retinal oximetry.

Risk Factors for Open-angle Glaucoma in Persons of Latin American Descent.

OAG represents a growing concern among persons of LAD in the United States; however, information on specific risk factors in this population currently remains limited.

Management of Glaucoma in Pregnancy.

Thus, managing glaucoma in pregnancy is a delicate balance between treatment to prevent damage to the optic nerve in the mother and avoidance of interventions potentially harmful to the fetus.

Glaucoma Treatment Outcomes in Open Angle Glaucoma Patients of African Descent.

In addition to treatment outcomes, social disparities affecting clinical care also exist for AD persons in the form of reduced adherence, access, and choice.

Regional Vessel Density Reduction in the Macula and Optic Nerve Head of Patients With Pre-Perimetric Primary Open Angle Glaucoma.

In ppOAG patients, VD biomarkers in both the macula and ONH, alongside RNFL, GCC, and macular thickness, were significantly reduced before detectable visual field loss with regional specificity.

Twelve-Year Incidence of Open-angle Glaucoma: The Thessaloniki Eye Study.

The incidence of OAG was similar or higher compared with other White populations. The incidence of glaucoma in those with PEX was higher compared with the incidence of glaucoma in those without PEX.

Deep Learning for Localized Detection of Optic Disc Hemorrhages.

An autonomous object detection model is superior to an image classification model for detecting disc hemorrhages, and performed comparably to 2 clinicians.

Clinical implications of retinal oximetry in retinal vein occlusion: a review.

The current literature on retinal oxygenation in ischaemic subtypes of RVO and in drug therapies is minimal, and further work is required to expand upon our understanding of how ischaemia and drugs influence retinal oxygenation…

Association Between Dietary Salt Intake and Open Angle Glaucoma in the Thessaloniki Eye Study.

In TES participants assessed for OAG in the prevalence and incidence phases, frequent salt intake may be associated with increased OAG in those who take antihypertensive medication.

The role of hypertension in retinal blood flow alterations in open-angle glaucoma patients.

Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma.

Neural network models indicate that OCTA optic nerve head vascular biomarkers are equally useful for ML diagnosis of POAG when compared to OCT structural biomarker features alone.

Vascular Density and Retinal Structure Relationships Across Sectors and Regions of the Optic Nerve in Patients With Primary Open Angle Glaucoma.

Early-stage POAG patients have a stronger relationship between RPC VD and RNFL in the temporal regions of the ONH compared with non-glaucomatous controls, with the TS sector demonstrating the largest difference between groups.

Lessons From The Glaucoma Foundation Think Tank 2023: A Patient-Centric Approach to Glaucoma.

The experts agreed on the importance of genetics in defining individual POAG risk and highlighted the additional crucial role of lifestyle, gender, blood pressure, and vascular risk factors.

Response to: Risk Factors for Open-angle Glaucoma in Persons of Latin American Descent.

Alzheimer's disease and primary open-angle glaucoma associated with vascular health in patients of African descent.

Response to: The Influence of Translaminar Pressure Gradient and Intracranial Pressure in Glaucoma.

Response: Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-Angle Glaucoma: The Effect of Orgasm and Sexual Activity.

ChatGPT-Assisted Glaucoma Diagnosis: A Health-Equitable Multi-Ancestry Analysis Using Visual Field and Optical Coherence Tomography Data.

ChatGPT o1 Pro diagnosed glaucoma similarly to specialists using only VF and OCT data. The model performance was similar across ancestral groups and genetic predispositions to glaucoma.

Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina.

Model predictions indicate that isolated or combined vascular impairments in CD, flow regulation, and IOP contribute to poor retinal tissue oxygenation, which could lead to vision loss in advanced glaucoma patients.

Disc Hemorrhages in Open-Angle Glaucoma-Between a Rock and a Hard Place?

Response to: Management of Glaucoma in Pregnancy.

Ocular blood flow biomarkers may predict long-term glaucoma progression.

In our OAG sample, baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years.

Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist: Results of a Randomized, Placebo-controlled, Dose Escalation Study.

ONO-9054 was well-tolerated and elicited dose-dependent reductions in IOP, which were sustained for at least 24 hours following 2 weeks of consecutive daily dosing.

Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes.

This study suggests that retrobulbar blood flow is lower in healthy eyes in persons of AD compared with ED.

Reductions in Retrobulbar and Retinal Capillary Blood Flow Strongly Correlate With Changes in Optic Nerve Head and Retinal Morphology Over 4 Years in Open-angle Glaucoma Patients of African Descent Compared With Patients of European Descent.

Reductions in retinal capillary and retrobulbar blood flow strongly correlated with changes in the ONH and macular thickness over 4 years in OAG patients of AD compared with ED.

Neuroretinal rim area and ocular haemodynamic parameters in patients with normal-tension glaucoma with differing intracranial pressures.

Patients with NTG having lower ICP have decreased neuroretinal rim area and OA blood flow parameters compared with patients having higher ICP.

Serum antiphospholipid antibody level and ocular haemodynamics in eyes with pseudoexfoliation syndrome.

Vascular Dysfunction in Diabetes and Glaucoma: A Complex Relationship Reviewed.

A literature review of published population-based studies was performed, with a focus on studies regarding blood flow abnormalities.

The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period.

Reductions in retrobulbar and retinal blood flow over time were associated with structural glaucomatous progression, as indicated by retinal and optic nerve changes.

Update in intracranial pressure evaluation methods and translaminar pressure gradient role in glaucoma.

Special emphasis is put on the two-depth transcranial Doppler technology, which uses an ophthalmic artery as a natural ICP sensor.

Surrogates for ocular perfusion pressure are not perfect--authors reply.

Differences in ocular blood flow in glaucoma between patients of African and European descent.

Significantly lower blood flow values were identified in all retrobulbar blood vessels in AD compared with ED OAG patients.

Effect of Trabeculectomy on Ocular Hemodynamic Parameters in Pseudoexfoliative and Primary Open-angle Glaucoma Patients.

Trabeculectomy resulted in a significant decrease in IOP and increase in ocular blood flow.