Hashimoto Kazuki

Genetic Variants Associated With the Onset and Progression of Primary Open-Angle Glaucoma.

The results indicate that non-IOP-related (optic nerve vulnerability) rather than IOP-related (IOP elevation) genetic variants may play an important role in the onset of POAG (family history of glaucoma) and that IOP-related rather than non-IOP-related…

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study.

Integrated metabolomic profiles identified five distinct etiologic endotypes of OAG, suggesting pathological mechanisms related with a high-risk group of central vision loss progression in the Japanese population.

Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals.

The GRS showed moderate discriminative accuracy for POAG in the Japanese population.