Hollitt Georgina L

Attitudes Towards Polygenic Risk Testing in Individuals with Glaucoma.

These findings will help to facilitate the clinical implementation of PRS testing for glaucoma to reduce irreversible vision loss.

High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma.

This study demonstrated novel associations between glaucoma polygenic risk and risk of commencement or escalation of IOP-lowering therapy, building on previous work highlighting the potential clinical usefulness of genetic risk stratification in glaucoma.

A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation.

The PRSs for open-angle glaucoma, IOP, and VCDR stratify risk of glaucoma development and disease severity among individuals with PEX.

Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.

Our results show strong interest in genetic risk assessment for glaucoma among unaffected individuals in Australia.

Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study.

These results highlight the potential neuroprotective benefits of exercise on the human retina.

High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.

This report identified clinically relevant correlations between glaucoma PRS and the need for surgical intervention in patients with glaucoma.

Uptake of Polygenic Risk Testing for Glaucoma in Unaffected Individuals.

This is the first study to demonstrate the potential uptake of polygenic testing for glaucoma among an unaffected population.

Healthcare professionals' knowledge and attitudes towards polygenic risk testing for glaucoma.

Our findings indicated that multiple groups of healthcare professionals were neither familiar nor confident with the concept of glaucoma polygenic risk testing, and identified training and education needs to support the implementation of testing into…