Huang Jingjing

Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation.

We demonstrated that SRT2104 exerted potent protective effects against I/R injury by enhancing Sirt1-mediated deacetylation and suppressing apoptosis, senescence, and neuroinflammation-related pathways.

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension-Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice.

PACAP could prevent the loss of retinal tissue and improve the survival and function of RGCs. The neuroprotective effect of PACAP is probably associated with its potent anti-apoptotic and anti-inflammatory effects.

Occurrence of Oxidative Stress and Premature Senescence in the Anterior Segment of Acute Primary Angle-Closure Eyes.

Oxidative stress and premature senescence occurred in the anterior segment of APAC patients, suggesting that they may be involved in the development of pathological changes in the anterior segment of APAC eyes.

The Relationship Between Binocular Visual Field Loss and Various Stages of Monocular Visual Field Damage in Glaucoma Patients.

The BVF can remain relatively intact provided one eye is at the normal or early stage.

Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.

Our results suggested that DSCR1 might protect the RGCs against oxidative stress via the CREB-Bcl-2 pathway, which may provide a theoretical basis for future treatments of glaucoma.

Efficacy and Safety of Surgical Peripheral Iridectomy, Goniosynechialysis, and Goniotomy for Advanced Primary Angle Closure Glaucoma Without Cataract: 1-Year Results of a Multicenter Study.

The combination of SPI, GSL, and GT is a safe and effective surgical approach for advanced PACG without cataract. It has great potential as a first-line treatment option for these patients.

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma.

Ferroptosis significantly contributes to RGC and retinal damage in the GLAST-deletion NTG model. Inhibiting ferroptosis with Fer-1 presents a promising therapeutic strategy for protecting visual function in NTG.

Ocular Biometric Characteristics in Preoperative Diagnosis of Acute Angle Closure With and Without Zonular Laxity.

Binocular difference of ACD, LV in affected eyes, and binocular difference of LV had high efficiency in diagnosing AAC with zonular laxity.

Peripapillary intrachoroidal cavitation in myopic eyes with open-angle glaucoma: association with myopic fundus changes.

PICC was more prevalent in eyes with myopia and coexisting OAG than in eyes with myopia alone.

Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.

In this randomized clinical trial among patients with advanced PACG without cataract, SPI + GSL + GT demonstrated noninferiority (4-mm Hg margin) to trabeculectomy for IOP at 12 months, with fewer interventions (including bleb massage, suture lysis, or releasable sutures) but no difference in postoperative medication use.

Multi-Quantitative Assessment of AS-OCTA Complemented AS-OCT for Monitoring Filtering Bleb Function After Trabeculectomy.

The quantitative vascular characteristics detected by AS-OCTA were significant for the bleb monitor. The MVMS-BH-MCS grading system had achieved outstanding accuracy in reflecting the surgical results.

Asymmetry of Macular Vessel Density in Bilateral Early Open-angle Glaucoma With Unilateral Central 10-2 Visual Field Loss.

Significant macular microvascular damage was present in glaucomatous eyes without detectable 10-2 visual field damage.

Relationships of Paracentral Scotoma With Structural and Vascular Parameters in Highly Myopic Eyes With Early Open Angle Glaucoma.

Compared with low-to-moderate myopia, highly myopic eyes with early OAG were more likely to develop paracentral scotoma.

Bilateral Fundus Hypopigmentation in a Patient With Glaucoma.

Knowledge of Glaucoma Among New Patients to a Tertiary Eye Care Center in China.

Patients at tertiary eye care centers lack glaucoma knowledge, despite experience with eye care providers previously. Implementing health education at all levels is crucial in preventing glaucoma-related visual impairment.

Quantitative Measurements of the Ciliary Body in Eyes With Acute Primary-Angle Closure.

Ciliary bodies were thinner and more anteriorly rotated in eyes with APAC as well as in their fellow eyes. Further studies are needed to elucidate the relationship between ciliary body parameters and mechanism of APAC.

Author reply: To PMID 24321140.

Comparison of ocular biometry between eyes with chronic primary angle-closure glaucoma and their fellow eyes with primary angle-closure or primary angle-closure suspect.

Lens thickness, lens location, and axial length do not appear to play a significant role in the progression from PAC/PACS to CPACG.