Joan L. Jefferys

The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa.

The stiffness of the LC pressure-strain response was greater in diagnosed glaucoma eyes and varied with glaucomatous axon damage.

Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera.

The explant inflation test measures the strain response of the mouse ONH to applied IOP. Initial studies indicate regional differences in response to both acute and chronic IOP elevation within the ONH region.

Regional Retinal Ganglion Cell Axon Loss in a Murine Glaucoma Model.

There was selectively greater loss of superior and temporal optic nerve axons of RGCs in mouse glaucoma at certain stages of damage. Differences in nerve area change suggest non-RGC responses differ between mouse strains.

Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve.

The changes in structure elucidated IOP-generated alterations that underlie astrocyte mechanotranslational responses relevant to glaucoma.

Use of Optical Coherence Tomography by Nonexpert Personnel as a Screening Approach for Glaucoma.

OCT imaging may be performed by nonprofessional photographers on undilated patients, and quantitative parameters derived from the resultant images, particularly the vertical cup to disc ratio and the RNFL inferior quadrant thickness, demonstrate sensitivities and…

Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images.

Automated identification of ONH structures is comparable to observer markings for BMO and anterior LC position, making BMO a practical reference plane for algorithmic analysis.

A Protective Eye Shield Reduces Limbal Strain and Its Variability During Simulated Sleep in Adults With Glaucoma.

Wearing a mask reduced limbal strain and variation in limbal strain during simulated FD sleep, particularly in eyes with past field worsening, as did some facial features.

Measured Changes in Limbal Strain During Simulated Sleep in Face Down Position Using an Instrumented Contact Lens in Healthy Adults and Adults With Glaucoma.

Contact with a pillow in FD position during simulated sleep produced a sustained strain increase in glaucoma eyes, particularly those eyes with past progressive visual field loss.

Adherence With the Use of Target Intraocular Pressure for Glaucoma Patients in a Large University Practice.

Target IOP was recorded in the large majority of patient charts, but its use varied by physician and patient characteristics.