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Small Extracellular Vesicle Treatment of Trabecular Meshwork Fibrosis: 2D/3D In Vitro and In Vivo Analyses.
hBMMSC sEVs significantly attenuate TGFβ2-induced TM fibrosis via both protein expression and morphological changes. In addition, hBMMSC sEVs have therapeutic potential in alleviating the TGFβ2-induced increase in IOP linked to TM fibrosis.