Joachim Stephanie C

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina.

In many cases, a replacement of in vivo research will mean that several different in vitro models are used in conjunction, for instance to analyze and validate causative molecular pathways.

Oxidative stress-induced retinal damage is prevented by mild hypothermia in an ex vivo model of cultivated porcine retinas.

Reduced apoptosis rates through hypothermia led to a preservation of RGCs (P < .001).

Specific Inner Retinal Layer Cell Damage in an Autoimmune Glaucoma Model Is Induced by GDNF With or Without HSP27.

Immunizations led to loss of RGCs and cholinergic amacrine cells and a strong increase in microglial cells.