Michael A. Kass

Central Corneal Thickness in the Ocular Hypertension Treatment Study (OHTS).

African American subjects have thinner corneas than white subjects in the study.

What We Have Learned From the Ocular Hypertension Treatment Study.

Clinicians and patients can make evidence-based decisions about the management of ocular hypertension using the risk model and considering patient age, medical status, life expectancy, and personal preference.

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

In this study, only one-fourth of participants in the Ocular Hypertension Treatment Study developed visual field loss in either eye over long-term follow-up.

Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning.

The model's high diagnostic accuracy using OHTS photographs suggests that DL has the potential to standardize and automate POAG determination for clinical trials and management.

Glaucoma Risk Alleles in the Ocular Hypertension Treatment Study.

The size of the OHTS cohort and its composition of 2 large racial subgroups may limit its power to detect some glaucoma risk factors.

Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.

Higher PRS was associated with increased risk for POAG in patients with ocular hypertension. The inclusion of a PRS improved the prediction of POAG onset.

Accuracy of Kalman Filtering in Forecasting Visual Field and Intraocular Pressure Trajectory in Patients With Ocular Hypertension.

These findings suggest that machine learning algorithms such as KF can accurately forecast MD, pattern standard deviation, and intraocular pressure 5 years into the future for many patients with OHTN.

Assessment of the Impact of an Endpoint Committee in the Ocular Hypertension Treatment Study.

Endpoint Committee adjudication of endpoints improved POAG incidence estimates, increased statistical power, and increased calculated treatment effect by 23%.

Evaluation of a Primary Open-Angle Glaucoma Prediction Model Using Long-term Intraocular Pressure Variability Data: A Secondary Analysis of 2 Randomized Clinical Trials.

Evidence from the OHTS and the EGPS suggests that long-term variability does not add substantial explanatory power to the prediction model as to which individuals with untreated ocular hypertension will develop POAG.

Fundus Densitometry Findings Suggest Optic Disc Hemorrhages in Primary Open-Angle Glaucoma Have an Arterial Origin.

DH have densitometry profiles comparable to MA and different from RVO, suggesting that DH in glaucoma have an arterial origin.

Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study.

OHTS DH had densitometric measurements more similar in magnitude to adjacent arterioles than venules, supporting an arterial origin for DH. Vascular dysregulation may contribute to disc hemorrhage formation in ocular hypertension.

Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status.

These findings support the need for further studies to confirm the association between POAG diagnosis and a decrease in mental health score and to develop strategies to inform patients about their POAG diagnosis without producing…

Visual Field Progression in the Ocular Hypertension Treatment Study.

Some participants in OHTS had rapid rates of VF loss in one or both eyes despite being followed in a clinical study.

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

These findings support considering use of a POAG PRS threshold to identify individuals at low risk of disease onset, with those below the PRS threshold more likely to have lower conversion rates over 20 years.

Clinical Application of the 20-Year Results from the Ocular Hypertension Treatment Study (OHTS)-Reply.

Anti-VEGF Injections and Glaucoma Surgery.

What is the Optimal Frequency of Visual Field Testing to Detect Rapid Progression Among Hypertensive Eyes?

Given the importance of not missing the conversion to glaucoma, the frequency of testing used in OHTS (6 mo) was optimal for the detection of progression in high-risk patients.

Comparing glaucomatous disc change using stereo disc viewing and the MatchedFlicker programme in glaucoma experts and trainees.

Both expert glaucoma specialists and ophthalmologists in various stages of training had greater accuracy and speed with the MatchedFlicker programme than with a handheld stereoscopic viewer.

Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study.

In this cross-sectional study, among the surviving participants of OHTS who completed the 20-year follow-up examination, those participants who developed preperimetric POAG but no glaucomatous VF loss did not report lower VFQoL compared with participants who did not develop POAG.

Design and Baseline Characteristics of Participants in the Clarifying the Optimal Application of Selective Laser Trabeculoplasty (SLT) Therapy (COAST) Trial 1.

The COAST trial compares standard versus low-energy SLT for new ocular hypertension/glaucoma. Its robust design and representative patient population will clarify optimal SLT use for long-term glaucoma management, potentially reducing reliance on other therapies.

Visual field progression patterns in the ocular hypertension treatment study correspond to vulnerability regions of the disc.

Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss.

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.

Our integrative study is the first to associate rs76481776 with POAG via elevated miR-182 expression.

Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension.

Methods for identifying objective, quantitative measurements of 3D ONH structure were developed using a large dataset.