Young Kook Kim

Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-analysis.

For each unit (1-D) increase in myopia, the risk of glaucoma increases by approximately 20%. The risk more steeply increases in high-degree myopia, representing a significant nonlinear relationship.

Temporal Relation between Macular Ganglion Cell-Inner Plexiform Layer Loss and Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma.

In eyes with early glaucoma, mGCIPL change is frequently detected before corresponding pRNFL change.

Trend-based Analysis of Ganglion Cell-Inner Plexiform Layer Thickness Changes on Optical Coherence Tomography in Glaucoma Progression.

The GCIPL thinning rate on OCT was significantly faster for patients with glaucoma with progression than for those without progression.

Diagnosing Glaucoma With Spectral-Domain Optical Coherence Tomography Using Deep Learning Classifier.

An SD-OCT-based deep learning system can detect glaucomatous structural change with high sensitivity and specificity.

Diagnostic Ability of Wide-field Retinal Nerve Fiber Layer Maps Using Swept-Source Optical Coherence Tomography for Detection of Preperimetric and Early Perimetric Glaucoma.

The wide-field RNFL thickness map using SS-OCT performed well in distinguishing eyes with PPG and EG from healthy eyes.

Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes.

In highly myopic eyes, determination of the presence or absence of GCIPL thickness difference across the temporal raphe via OCT macula scan can be a useful means of distinguishing the glaucomatous damage.

Inferior Macular Damage in Glaucoma: Its Relationship to Retinal Nerve Fiber Layer Defect in Macular Vulnerability Zone.

There was no single case of pRNFL defect in the MVZ without inferior mGCIPL loss.

Baseline Lamina Cribrosa Curvature and Subsequent Visual Field Progression Rate in Primary Open-Angle Glaucoma.

The baseline maLCCI showed a significant correlation with the rate of subsequent VF deterioration.

Temporal Raphe Sign for Discrimination of Glaucoma from Optic Neuropathy in Eyes with Macular Ganglion Cell-Inner Plexiform Layer Thinning.

In clinical practice, determining whether the temporal raphe sign appears on OCT macular scans can be a useful tool for discrimination of glaucomatous from nonglaucomatous mGCIPL thinning.

Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis.

We determined the GCIPL thinning rates for normal and undertreated OAG and PXG eyes. Differences existed among the normal eyes and glaucoma types, with PXG progressing significantly faster than OAG.

Combined Use of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Event-based Progression Analysis.

The various progression patterns were confirmed according to the locations and baseline patterns of glaucomatous structural change on the integrated GPA map (GPA PanoMap).

Understanding the reasons for loss to follow-up in patients with glaucoma at a tertiary referral teaching hospital in Korea.

This study's results emphasise the need for ongoing educational support and improved appointment notification, especially for the elderly, men and patients with low baseline intraocular pressure.

Serial Combined Wide-Field Optical Coherence Tomography Maps for Detection of Early Glaucomatous Structural Progression.

The serial combined wide-field OCT maps integrating RNFL and GCIPL maps performed well in detecting structural progression in early glaucomatous eyes. Confirmation in an independent prospective study might provide greater confidence in this conclusion.

Development of Topographic Scoring System for Identifying Glaucoma in Myopic Eyes: A Spectral-Domain OCT Study.

Our scoring system including OCT topographic parameters demonstrated to be beneficial for clinicians to differentiate real glaucomatous damage from myopic healthy eyes.

Ten Years and Beyond Longitudinal Change of ß-Zone Parapapillary Atrophy: Comparison of Primary Open-Angle Glaucoma with Normal Eyes.

The pattern of ß-zone PPA change differed between POAG and normal eyes during a follow-up of 10 years or more.

Comparison of Optical Coherence Tomography Structural Parameters for Diagnosis of Glaucoma in High Myopia.

Results of this cross-sectional study suggest that in discriminating glaucomatous eyes in patients with high myopia, inferotemporal GCIPL thickness yielded the highest AUROC value.

Rate of Macular Ganglion Cell-inner Plexiform Layer Thinning in Glaucomatous Eyes With Vascular Endothelial Growth Factor Inhibition.

In subjects with bilateral OAG, the rate of GCIPL thinning is significantly faster in eyes treated with anti-VEGF injection for wet AMD than in untreated dry AMD fellow eyes.

Twenty-four-Hour Intraocular Pressure-Related Patterns from Contact Lens Sensors in Normal-Tension Glaucoma and Healthy Eyes: The Exploring Nyctohemeral Intraocular pressure related pattern for Glaucoma Management (ENIGMA) Study.

Continuous monitoring of 24-hour IOP-related values with CLS can be useful for assessment of glaucoma risk, especially for patients with NTG whose IOP appears to be in the normal range.

Ellipsoid Zone Change According to Glaucoma Stage Advancement.

According to SD-OCT, relative EZ intensity reduction occurs in the mild-to-moderate and severe glaucoma stages.

Pre-perimetric Open Angle Glaucoma with Young Age of Onset: Natural Clinical Course and Risk Factors for Progression.

In untreated pre-perimetric OAG patients with a "young age of onset" condition, the estimated MD slope for the disease course of more than 5 years was -0.03 dB/y, and the average RNFL thinning rate was -0.46 μm/y.

Facial Port-Wine Stain Phenotypes Associated with Glaucoma Risk in Neonates.

Among the newborns with facial PWS, 1) a greater extent of birthmarks involving the S2 area, and 2) lesions including the lower eyelid were associated with higher risk of glaucoma development within the neonatal period.

Evaluation of Optic Nerve Head and Peripapillary Choroidal Vasculature Using Swept-source Optical Coherence Tomography Angiography.

The prelaminar region of the optic nerve head might be supplied by the peripapillary choroid in addition to the known major blood supply from the short posterior ciliary arteries.

Interventions for Glaucoma Medication Adherence Improvement: A Network Meta-analysis of Randomized Controlled Trials.

The NMA indicated that tailored care can improve adherence to glaucoma medication compared with SOC. A multifaceted approach might yield additional improvements.

Comparison of Efficacy and Safety of Bleb Needle Revision With and Without 5-Fluorouracil for Failing Trabeculectomy Bleb.

Bleb needle revision with 5-FU subconjunctival injection is a safe procedure for failing trabeculectomy bleb. Bleb needle revision with and without 5-FU were equally likely to succeed.

Incidence of retinal vein occlusion in open-angle glaucoma: a nationwide, population-based study using the Korean Health Insurance Review and Assessment Database.

The RVO incidence rate for OAG patients is significantly higher than that for the general population.

Incidence of Sturge-Weber Syndrome and Risk of Secondary Glaucoma: A Nationwide Population-based Study Using a Rare Disease Registry.

This study identified birth-cohort SWS incidence and determined secondary-glaucoma risk in a population of East Asian ethnicity. These data could help to promote better understanding of the epidemiologic features of SWS patients.

Evaluation of Retinal Nerve Fiber Layer Thinning in Myopic Glaucoma: Impact of Optic Disc Morphology.

Our results suggest that the optic disc torsion-glaucomatous damage correspondence is an important prognostic factor for patients with myopic open-angle glaucoma.

Evaluation of Ganglion Cell-Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis.

The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH.

Evaluation of Layer-by-Layer Segmented Ganglion Cell Complex Thickness for Detecting Early Glaucoma According to Different Macular Grids.

Large macular grids have generally high discriminating power for the diagnosis of early glaucoma by SD-OCT.

Association of Optic Disc Tilt and Torsion with Open-Angle Glaucoma Progression Risk: Meta-Analysis and Meta-Regression Analysis.

Evidence for the effects of optic nerve deformation on glaucoma progression is still lacking. Future research using stratified analysis according to age and tailored diagnostic criteria will allow for more rigorous analyses for this topic.

Incidence of Open-angle Glaucoma in Newly Diagnosed Retinal Vein Occlusion: A Nationwide Population-based Study.

The incidence rate of OAG in patients with RVO is significantly higher than that in the general population.

Relationship Between Open-angle Glaucoma and Stroke: A 2010 to 2012 Korea National Health and Nutrition Examination Survey.

Although there was no overall statistical significance, patients with OAG had an increased risk of stroke, among those with systemic comorbidities, including hypertension and diabetes.

Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study.

Sovesudil 0.25% and 0.5% TID showed statistically significant IOP-lowering effects and 0.5% concentration's IOP-lowering effects met the superiority criteria in comparison with the placebo at week 4.

Decision Tree Algorithm-Based Prediction of Vulnerability to Depressive and Anxiety Symptoms in Caregivers of Children With Glaucoma.

Evaluation of the number of glaucoma surgeries and VA in the better eye can be a useful decision support tool in predicting mental illness in caregivers of children with glaucoma.

Association of Angle Width With Progression of Normal-Tension Glaucoma: A Minimum 7-Year Follow-up Study.

Narrow-angle NTG showed a greater probability of disease progression than did wide-angle NTG. Further studies determining whether augmented or differentiated treatment strategies would be beneficial for patients with narrow-angle NTG are warranted.

Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma?

Structural changes on SS-OCT probability maps could detect or predict VF changes using SAP, in a considerable number of PPG eyes.

Association between Sight-Threatening Eye Diseases and Death by Suicide in South Korea: A Nationwide Population-based Cohort Study.

In South Korea between 2010 and 2020, a higher suicide rate was evident among those with diagnosed STED than for persons not so diagnosed.

Temporal Raphe Sign in Elderly Patients With Large Optic Disc Cupping: Its Evaluation as a Predictive Factor for Glaucoma Conversion.

In elderly subjects with large CDR, temporal raphe sign positivity on the baseline macular GCIPL thickness map was associated with faster conversion to NTG.

Diurnal Variation of Choroidal Thickness in Primary Open-angle Glaucoma.

The mCT in the POAG patients did not increase in the evening relative to the healthy subjects' pattern. However, the diurnal mCT values measured in the healthy subjects and POAG patients were not statistically significant.

Measurement of Optic Disc Cup Surface Depth Using Cirrus HD-OCT.

In early-to-moderate glaucoma, the cup surface depth changed faster than did the RNFL thickness.

Placebo Effect and Its Determinants in Ocular Hypotensive Therapy: Meta-analysis and Multiple Meta-regression Analysis.

The placebo effect has been studied and documented within a wide clinical context. It remains unclear whether placebo is effective in glaucoma treatment or, if so, which factors are determinative of effect size (ES).

Rate of Progression Among Different Age Groups in Glaucoma With High Myopia: A 10-Year Follow-Up Cohort Study.

The glaucoma progression rate in highly myopic NTG showed a bimodal pattern based on the age at presentation, younger patients exhibiting faster progression compared to older patients.

Long-Term Follow-Up of Myopic Glaucoma: Progression Rates and Associated Factors.

In patients with myopic glaucoma, the higher the degree of myopia, the faster the rate of visual acuity loss and CVFD occurrence.

Macular sector-wise decision tree model for the prediction of parafoveal scotoma not detected by 24-2 visual field test.

In clinical practice, the evaluation of the 24-2 perifoveal test points along with the probability colour codes of mGCIPL can be a useful decision-support tool in determining whether 10-2 tests are needed for a given…

Interdigitation Zone Change According to Glaucoma-Stage Advancement.

SD-OCT revealed a reduction in IZ area in NTG eyes, and the extent of the reduction was positively associated with glaucoma severity.

Long-Term Follow-up on Glaucoma Patients With Initial Single-Hemifield Defect: Progression Patterns and Associated Factors.

In 108 POAG eyes with an initial single-hemifield defect, 41.7% showed involvement of the opposite hemifield during the average 8.0-year follow-up.

Clinical Implications of In Vivo Lamina Cribrosa Imaging in Glaucoma.

LC deformation in glaucoma typically has been evaluated in terms of its position from a structural reference plane (LC depth), entire curvature or shape, thickness, or localized structural change (focal LC defects or LC pore change).

Effects of nicotinamide supplementation in normal-tension glaucoma: a crossover placebo-controlled randomised clinical trial.

Oral NAM supplementation in NTG participants induced functional improvement, as measured by PhNRPT and B-wave amplitude.

Assessing Glaucoma Severity and Progression in Individuals with Asymmetric Axial Length: An Intrapatient Comparative Study.

When an axial length difference of more than 1.0 mm was present, glaucoma tended to be more severe and to progress faster in the longer eyes.

Nationwide Incidence of Infantile Cataract Surgery and Risk of Secondary Glaucoma in a Population-based Birth Cohort.

This study identified the birth cohort incidence of IC surgery and secondary glaucoma risk in individuals of East Asian ethnicity.

Association of Intereye Visual-Sensitivity Asymmetry With Progression of Primary Open-Angle Glaucoma.

Among POAG eyes with comparable hemifield VFDs, eyes without a corresponding hemifield defect in the fellow eye showed faster rates of progression compared with those with a corresponding hemifield defect.

Optic Disc Microhemorrhage in Primary Open-Angle Glaucoma: Clinical Implications for Visual Field Progression.

Micro-DH was found prior to macro-DH detection in a significant proportion of POAG patients; micro-DH, moreover, was associated with earlier and faster VF progression.

Comparison of Patterns of Structural Progression in Primary Open Angle Glaucoma and Pseudoexfoliation Glaucoma.

OCT GPA showed progression patterns of RNFL and GCIPL thinning in POAG and PXG.

SMOTE-Enhanced Explainable Artificial Intelligence Model for Predicting Visual Field Progression in Myopic Normal Tension Glaucoma.

The SMOTE-enhanced AI model shows reasonable predictive performance and potential clinical utility for identifying visual field progression in myopic NTG patients, though further validation in larger cohorts is needed.

Natural History of Optic Disc With Physiologic Large Cup: Incidence, Predictors of Glaucoma Conversion After Minimum 10-Year Follow-up.

This study identified the prevalence of PLC as well as the incidence rate of glaucoma conversion and the risk factors for glaucoma development in PLC eyes.

Predicting the Therapeutic Efficacy of Laser Peripheral Iridotomy for Individuals With Asymptomatic Narrow Angle: The Triple Hump Sign.

PACS eyes indicating the positive-TH sign showed, at post-LPI 1 month, a greater IOP decrease.

Valsalva Maneuver-induced Changes in Anterior Lamina Cribrosa Surface DEPTH: A Comparison Between Normal and Glaucomatous Eyes.

During the VM, the ALCSD was decreased in normal eyes, but was not significantly changed in eyes with treated glaucoma.

Comparison of Glaucoma Progression Between Unilateral and Bilateral Disc Hemorrhage Eyes and Associated Risk Factors for Progression.

In bilateral POAG patients with DH, unilaterality of DH is associated with glaucoma progression.

Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma: methodological issues of prediction model - response.

Incidence of and Risk Factors for Fellow-Eye Involvement in Sturge-Weber Syndrome Children With Unilateral Glaucoma.

In this cohort of SWS children diagnosed with unilateral glaucoma, the risk of fellow-eye involvement was higher in girls, within the first 4 years, and in cases with choroidal hemangioma.

Analysis of Variation in Incidence of Optic Disc Hemorrhage According to Seasonal and Temperature Changes.

DH is affected by temperature, and as such, shows seasonal variability. This variability is believed to be caused by temperature-related factors such as IOP or hematological factors. © 2022 Elsevier Inc. All rights reserved.

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Conversion of Single Optic Disc Photography into 3-Dimensional Image.

Optic Disc Hemorrhage in a 6-Year-Old Boy with Treated Congenital Glaucoma.

Preperimetric glaucoma: conversion to primary open-angle glaucoma in a 10-year follow-up.

This study of PPG with more than 10 years of follow-up demonstrates a substantial proportion (35.5%) converting to POAG, highlighting the need for long-term monitoring in these patients.

Factors influencing glaucoma severity in highly myopic glaucoma.

Mild group showed less ONH deformation and shorter AXL. Both regression and SEM analyses support the role of ONH structural changes-particularly β-zone PPA and disc tilt-in influencing glaucomatous damage in highly myopic eyes.

Corrigendum to "Association Between Alpha-Blockers for Benign Prostatic Hyperplasia and Acute Angle-Closure Glaucoma". Am J Ophthalmol. 2026;282:197-205.

Association Between Alpha-Blockers for Benign Prostatic Hyperplasia and Acute Angle-Closure Glaucoma.

This study demonstrates a significant, duration-dependent association between α-blocker use for BPH and an increased risk of AACG.

Synergistic effects of glaucoma, degeneration of macula and posterior pole, and diabetic ophthalmic complications on vision loss.

The presence of multiple ARODs significantly elevates the risk of severe VI. These findings emphasise the need for integrated eye care, including prevention of developing additional ARODs.

Associations Between IgE-Allergen Sensitization and Glaucoma: An Analysis of Korea National Health and Nutrition Examination Survey.

Our findings suggest a complex relationship between allergen sensitization and glaucoma, with different allergens showing varying associations with disease risk.

Clinical Significance of Optic Disc Hemorrhage Size in Visual Field Progression in Glaucoma.

DH size was associated with the rate of VF deterioration. Eyes with larger DH showed more pronounced VF progression.

Trends in Childhood Glaucoma Prevalence and Incidence in South Korea, 2002-2019: A Nationwide Population-Based Study.

This study identified childhood glaucoma prevalence and incidence in a general population of East Asian ethnicity.

Patterns of Optical Coherence Tomography Imaging in Preperimetric Open Angle Glaucoma: A Comparative Study With Young-Age-Onset and Old-Age-Onset Eyes.

Young-age-onset and old-age-onset eyes of preperimetric OAG present different specific patterns of RNFL and GCIPL thinning.

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In Reply: Comparison of Glaucoma Progression Between Unilateral and Bilateral Disc Hemorrhage Eyes and Associated Risk Factors for Progression.

Residual Structural Differences on Anterior Segment OCT After Laser Peripheral Iridotomy in Primary Angle Closure Disease.

After laser iridotomy for primary angle closure disease, anterior segment OCT reveals persistent structural differences, particularly in anterior chamber depth and nasal angle parameters. This offers a useful adjunctive tool for assessing and stratifying risk in treated eyes.

Intraocular pressure reduction and progression of highly myopic glaucoma: a 12-year follow-up cohort study.

Glaucoma progression is associated with amount of IOP reduction by topical medications in highly myopic eyes, and DH occurrence is a glaucoma progression risk factor.

Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects.

DL models, trained with both fundus images and clinical data, showed the potential to predict whether and when normotensive GS patients will show conversion to NTG.

Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma.

Intraocular lens power predictions for cataract surgery in PAC or PACG patients can be inaccurate.

Lamina cribrosa defects in eyes with glaucomatous disc haemorrhage.

Focal LC defects are more frequently visible in eyes with glaucomatous DH than in eyes without DH.

Prelamina and Lamina Cribrosa in Glaucoma Patients With Unilateral Visual Field Loss.

In the fellow eyes with unilateral glaucoma patients, APLD was significantly greater, and the prelaminar tissue was significantly thinner, than in the healthy control eyes.

Topographic correlation between optic nerve head characteristics and retinal nerve fibre layer defect in primary open-angle glaucoma patients: Korea National Health and Nutrition Examination Survey.

In the Korean POAG patients examined, the directions of the PMRE of β-zone PPA and of the optic disc torsion showed significant associations with the RNFL defect location.

Effect of Focal Lamina Cribrosa Defect on Disc Hemorrhage Area in Glaucoma.

The DHs that correspond to FLCD location tend to have larger areas and to be more proximally located than those without correspondence. This suggests that FLCD might affect the topographic characteristics of DH.

Automated Detection of Hemifield Difference across Horizontal Raphe on Ganglion Cell--Inner Plexiform Layer Thickness Map.

For discrimination of early glaucomatous structural loss, most notably in preperimetric glaucoma cases, identification of the GCIPL thickness difference across the horizontal raphe was effective.

Prevalence of Optic Disc Hemorrhage in Korea: The Korea National Health and Nutrition Examination Survey.

The prevalences of DH among Koreans are similar to the figures reported by previous population-based studies for the same age ranges.