King Anthony J

Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma-study protocol.

Treatment of Advanced Glaucoma Study will be the first RCT reporting outcomes from the perspective of those with advanced glaucoma.

Exploring literature-based definitions of hypotony following glaucoma filtration surgery and the impact on clinical outcomes.

Variations in defining postoperative hypotony can have a large impact on the reported success and failure rates among studies.

Profiling ocular surface responses to preserved and non-preserved topical glaucoma medications: A 2-year randomized evaluation study.

BAK-preserved topical drops stimulate a sterile inflammatory response on the OS within 3 months which is maintained thereafter, whereas PF-drops and PQ-preserved drops showed no significant OS inflammation.

Survey of glaucoma surgical preferences and post-operative care in the United Kingdom.

Almost all the participants (74/75: 99%) routinely performed trabeculectomy, 54 responders (72%) undertook tube surgery and Minimally Invasive Glaucoma Surgery (MIGS) was more frequently undertaken (33.0%) than non-penetrating surgery (23%).

Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study.

At 5 years, the Treatment of Advanced Glaucoma Study demonstrated that primary trabeculectomy surgery is more effective in lowering IOP and preventing disease progression than primary medical treatment in patients with advanced disease and has a similar safety profile.

Reporting Harm in Glaucoma Surgical Trials: Systematic Review and a Consensus-Derived New Classification System.

Glaucoma surgical randomized controlled trials report frequency of complications, but their severity is rarely reported.

Reporting Complications in Glaucoma Surgery: A Systematic Review.

Outcome of repeat trabeculectomies: long-term follow-up.

Safe repeat trabeculectomy technique with antimetabolite titrated against the individual patients risk profile can result in improved results in the medium-term to long-term.

Baseline Characteristics of Participants in the Treatment of Advanced Glaucoma Study: A Multicenter Randomized Controlled Trial.

TAGS is the first RCT to compare medical versus surgical treatments for patients presenting with advanced open angle glaucoma in a publicly funded health service.

Classification of needling for trabeculectomy blebs.

Exploring the frequency and location of prescribing errors in the use of topical glaucoma medications.

Very little is known about health-care professional related prescribing errors within the glaucoma setting.

Validating and Updating the OHTS-EGPS Model Predicting 5-year Glaucoma Risk among Ocular Hypertension Patients Using Electronic Records.

We performed an external validation of the OHTS-EGPS model in a large English population.

Assessment of the level of harm resulting from glaucoma progression due to review delay.

For perimetric harm, the importance of the severity of the reference visual field as well as the importance of locational loss (central and inferior visual field) in defining harm, were highlighted.

Emerging perspectives in quality of life after trabeculectomy surgery.

The early post-operative period in trabeculectomy surgery is associated with a reversible loss of HRQoL, which is the result of transient worsening of vision but also physical, emotional and social restrictions caused by the busy medication regimen and drastic lifestyle changes.

Is primary trabeculectomy cost-effective for patients with advanced primary open angle glaucoma? Results from the Treatment of Advanced Glaucoma Study economic model.

In patients presenting with advanced POAG, trabeculectomy has a higher probability of being cost-effective over a patient's lifetime compared with medical treatment.

Validity of the Monocular Trial of Intraocular Pressure-Lowering at Different Time Points in Patients Starting Topical Glaucoma Medication.

The monocular trial of therapy is effective in accurately predicting the response of an untreated eye to monotherapy with a prostaglandin analogue at all daytime time points measured.

Short-term effect of diode laser cyclophotocoagulation on intraocular pressure: a prospective study.

IOP spikes are common in the immediate period after cyclophotocoagulation. An elevation in IOP is noted after the first hour in the vast majority who experience a spike in the first 3 h post-procedure.