Caroline C. W. Klaver

The Complications of Myopia: A Review and Meta-Analysis.

Although high myopia carries the highest risk of complications and visual impairment, low and moderate myopia also have considerable risks.

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population.

In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT.

Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study.

Results of this cohort study suggest that, although diabetes was clearly associated with cataract, diabetes medication was not.

A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma.

We identified a number of miRNAs that are associated with POAG endophenotypes. The identified miRNAs and their target genes are candidates for future studies on miRNA-related therapies for POAG.

Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations.

The significance of this finding is that higher numbers of healthy individuals in the population are expected to be carriers of this mutation, which in turn reduces the utility of identifying carriers of this mutation…

Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium.

We identified a potentially harmful association between use of CCBs and glaucoma prevalence.

Differences in clinical presentation of primary open-angle glaucoma between African and European populations.

In this multi-ethnic comparative study, Sub-Saharan Africans present at a younger age with lower visual acuity, higher IOP, larger VCDR, than SAC and Dutch participants.

Genetic African Ancestry Is Associated With Central Corneal Thickness and Intraocular Pressure in Primary Open-Angle Glaucoma.

This study demonstrated that a higher proportion of GAA was associated with a thinner CCT and a higher IOP in POAG patients.

Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut.

Large human studies exploring the link between the gut microbiome and glaucoma are lacking. Our results suggest that microbial dysbiosis plays a role in the pathophysiology of glaucoma.

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.

Using two complementary approaches we found no evidence to support a genetic overlap between myopia and POAG; our results suggest that the comorbidity of these diseases is not influenced by common variants.

Prevalence of Glaucoma in Europe and Projections to 2050: Findings from the European Eye Epidemiology Consortium.

The current and future burden of glaucoma in Europe may be substantially higher than previously estimated, with a considerable proportion of disease in the general population remaining undetected.

Genetic Associations Between Smoking- and Glaucoma-Related Traits.

MR experiments and GRS generated from Rotterdam Study participants support an inverse relationship between smoking and glaucoma.

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.

Incorporating a PRS into a POAG predictive model improves identification concordance from 0.75 up to 0.82, supporting its potential for guiding more cost-effective screening strategies.

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

In this cross-sectional study, despite some improvements in OR-based risk stratification using the Gharahkhani PRSs, Han PRSs, and Craig PRSs, consistently lower improvements in AUROC and R2 for African-ancestry compared with European-ancestry groups highlight the…

The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma.

Among participants with OAG, an increased cIMT was associated with a younger age at diagnosis. In patients with OAG and unexplained continuous progression, a screening ultrasound examination of the carotid arteries might be considered.

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization.

We found no evidence for a causal link between CCT and OAG. Nevertheless, CCT measurements are still valuable for population-based risk stratification. We found no clear relationship between FECD and OAG.