Michael S. Kook

Alterations of the Foveal Avascular Zone Measured by Optical Coherence Tomography Angiography in Glaucoma Patients With Central Visual Field Defects.

Microcirculatory alterations in the perifovea are spatially correlated with central VF loss. Loss of FAZ circularity was significantly associated with presence of CVFD, whereas FAZ area was significantly associated with severity of CVFD.

Regional vascular density-visual field sensitivity relationship in glaucoma according to disease severity.

Global and regional pVD measured by OCT-A was significantly associated with corresponding VFMS in moderate-to-advanced glaucoma. OCT-A may be useful in monitoring glaucoma at various stages.

Choroidal Microvasculature Dropout Is Associated With Parafoveal Visual Field Defects in Glaucoma.

The involvement of parafoveal VF defects was significantly associated with the presence of CMvD. Among eyes with CMvD, CMvD angular circumference had significant correlations with the severity of VF defects.

Choroidal Microvasculature Dropout is Not Associated With Myopia, But is Associated With Glaucoma.

CMvD was observed only in glaucomatous eyes and associated with severity of glaucomatous damage in myopic OAG subjects. The angular circumference of CMvD was significantly related to glaucoma severity.

Glaucoma Diagnostic Capabilities of Foveal Avascular Zone Parameters Using Optical Coherence Tomography Angiography According to Visual Field Defect Location.

The FAZ perimeter had good diagnostic capability in differentiating glaucomatous eyes with CVFDs from normal eyes, and may be a potential diagnostic biomarker for detecting glaucomatous patients with CVFDs.

Association Between Nocturnal Blood Pressure Dips and Optic Disc Hemorrhage in Patients With Normal-Tension Glaucoma.

Being an overdipper is a significant risk factor for ODH in NTG eyes. The detection of ODH during follow-up is a potent predictor of future VFP.

Baseline Systolic versus Diastolic Blood Pressure Dip and Subsequent Visual Field Progression in Normal-Tension Glaucoma.

Nocturnal trough DBP and DBP dip area at baseline are significant predictors of subsequent VF progression in NTG. Nocturnal DBP dip may be more relevant to future VF progression than SBP dip in NTG eyes.

An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density.

OCTA-derived FAZ area and perimeter showed statistically significant correlations with VDs measured at various retinal locations with spatial correspondence in OAG.

Greater Severity of Glaucomatous Damage in Eyes With Than Without Choroidal Microvasculature Dropout in Open-Angle Glaucoma.

OAG eyes with CMvD showed significantly lower cpRNFLT and mGCIPLT than those without CMvD at the hemiretinae corresponding to intact hemifields, thus requiring more vigilant attention for greater disease severity.

Association Between Progressive Retinal Capillary Density Loss and Visual Field Progression in Open-Angle Glaucoma Patients According to Disease Stage.

In OAG eyes, the rate of longitudinal cpCD loss was significantly associated with VF progression regardless of glaucoma stage.

An Increased Choroidal Microvasculature Dropout Size is Associated With Progressive Visual Field Loss in Open-Angle Glaucoma.

VF progression is significantly associated with a greater longitudinal increase in the CMvD AC in OAG eyes with CMvD. CMvD AC changes have significant correlations with the rate of VF loss.

Choroidal Microvasculature Dropout is Associated with Generalized Choroidal Vessel Loss within the β-Parapapillary Atrophy in Glaucoma.

Localized MvD was a strong predictor of generalized pCVD loss within the β-PPA in OAG eyes.

Topographic Relationship Between Optic Disc Torsion and ß-Zone Peripapillary Atrophy in the Myopic Eyes of Young Patients With Glaucomatous-appearing Visual Field Defects.

ODT direction showed a significant association with the locations of β-PPA and PMRE of β-PPA. Torsional degree was correlated with the β-PPA angle in the myopic eyes of young patients with glaucomatous-appearing VFDs.

Baseline Central Visual Field Defect as a Risk Factor For NTG Progression: A 5-Year Prospective Study.

NTG patients with baseline central VF involvement are at increased risk of progression compared with those with peripheral VF defect.

Comparison of the Circumpapillary Structure-Function and Vasculature-Function Relationships at Different Glaucoma Stages Using Longitudinal Data.

Significant longitudinal V-F relationships exist globally and regionally regardless of glaucoma stage but no longitudinal S-F relationship is present in advanced glaucoma.

Relationship Between Foveal Threshold and Macular Structure/Function/Vessel Density in Glaucoma.

Macular VD along with mGCIPL thickness and central 5 degrees VF MS independently predict FT outcomes even in the eyes of patients with early-to-moderate stage open-angle glaucoma.

Baseline Vessel Density Parameters for Predicting Visual Field Progression in Open-Angle Glaucoma Eyes With Central Visual Field Damage.

In eyes with OAG with CVF damage, a lower baseline pCVD in early-stage glaucoma and a reduced mGCIPL thickness at baseline in moderate to advanced glaucoma are significantly associated with subsequent VF progression.

Comparison of the 24-2 and 24-2C Visual Field Grids in Determining the Macular Structure-Function Relationship in Glaucoma.

A 24-2C grid may offer an advantage over the conventional 24-2 VF grid in assessing macular S-F relationships.

Patterns of Damage in Young Myopic Glaucomatous-appearing Patients With Different Optic Disc Tilt Direction.

The disc tilt direction may be related to asymmetrical pRNFL loss and the location and gravity of VF loss at initial presentation in young myopic glaucomatous-appearing patients.

Progressive Macular Vessel Density Loss and Visual Field Progression in Open-angle Glaucoma Eyes with Central Visual Field Damage.

Progressive mVD loss is significantly associated with VF progression (including central VF progression) in the OAG eyes with CVF loss regardless of the glaucoma stage.

Baseline Choroidal Microvasculature Dropout as a Predictor of Subsequent Visual Field Progression in Open-angle Glaucoma.

The presence of CMvD at baseline is an independent predictor of subsequent VF progression. CMvD(+) eyes show a faster rate of VFMS loss at the central and superior central VF regions.

Optic disc tilt direction affects regional visual field progression rates in myopic eyes with open-angle glaucoma.

Myopic OAG eyes show significantly different regional VF progression rates according to disc tilt direction.

Retinal Nerve Fiber Layer Damage in Young Myopic Eyes With Optic Disc Torsion and Glaucomatous Hemifield Defect.

Young myopic eyes with ODT and hemifield VF loss often show glaucomatous RNFL defects at both hemiretinas and significantly lower pRNFLT in the ODT-unaffected hemiretinas compared with matched hemiretinas of control eyes.

Morning Blood Pressure Surge and Glaucomatous Visual Field Progression in Normal-Tension Glaucoma Patients With Systemic Hypertension.

An increased MBPS at baseline is a significant independent predictor of subsequent VF progression in NTG patients with systemic hypertension.

Fast Central Visual Field Progression in Patients With Normal-Tension Glaucoma and Nocturnal Blood Pressure Dip.

Patients with NTG classified as over-dippers showed significantly faster central VF progression than non-dippers and dippers, with over 50% of over-dippers experiencing fast progression.

Association of 10-2 Visual Field Cluster Patterns With Visual Acuity in Normal-Tension Glaucoma Patients With Central Visual Field Defects.

HCA demonstrated consistent spatial patterns of CVFDs across various stages of NTG. The inferotemporal region (Cluster 3) consistently correlates with VA and serves as a key marker of VA loss.

Peripapillary Versus Macular Thinning to Detect Progression According to Initial Visual Field Loss Location in Normal-Tension Glaucoma.

mGCIPL outperforms pRNFL at early follow-up in detecting VF progression in IPFS eyes but not INS eyes.

Reply.

Reply.

Utility of targeted mean total deviation trend analysis for detecting progressive visual field changes in early-to-moderate stage glaucoma.

The rates of change in the TMTD are significantly faster than those for the mTD globally and in the VF-affected hemifields.

Association of baseline optical coherence tomography angiography with the development of glaucomatous visual field defects in preperimetric glaucoma eyes.

In PPG eyes, a lower baseline inferior temporal cpVD is significantly associated with glaucomatous VF defect development and a faster rate of global VF loss.

Reply.

Is Myopic Optic Disc Appearance a Risk Factor for Rapid Progression in Medically Treated Glaucomatous Eyes With Confirmed Visual Field Progression?

Open-angle glaucoma eyes with myopic optic disc appearance experiencing progressive VF changes showed similar VF progression rates globally and regionally when compared with nonmyopic eyes after controlling for clinical factors related to VF progression.

Reply: To PMID 26052089.

Macular structure-function relationship at various spatial locations in glaucoma.

The strength of the S-F associations at the temporal parafoveal location is significantly greater than that of the central or nasal parafoveal location in each hemimacula.

Relationship between daytime variability of blood pressure or ocular perfusion pressure and glaucomatous visual field progression.

Over-dipper NTG eyes showed significantly higher daytime or nighttime mean arterial pressure and ocular perfusion pressure variabilities than non-dipper and dipper NTG eyes.

Relationship Between Nocturnal Intraocular Pressure Elevation and Diurnal Intraocular Pressure Level in Normal-Tension Glaucoma Patients.

In NTG eyes with a low diurnal IOP, there are significant IOP increases at nighttime in the habitual position, whereas there is no significant nocturnal IOP elevation in NTG eyes with a high diurnal IOP.