Matthew H. Law

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

We found little genetic evidence supporting a causal association between SA and glaucoma.

Evaluating Practical Approaches for Including MYOC Variants Alongside Common Variants for Genetics-Based Risk Stratification for Glaucoma.

The p.Gln368Ter variant can be genotyped with high accuracy using array data, provided careful quality control measures are implemented. Incorporating p.Gln368Ter into glaucoma PRS improved risk stratification for carriers.

Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma.

We demonstrate that some clinically important rare variants can be reliably detected using arrays and imputation.