Lei Yuan

ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway.

Regulation of aqueous humor outflow via the caveolin-1/endothelial NO synthase/NO pathway is a newly defined function of ABCA1 that is different from its traditional role in mediating cholesterol efflux.

eNOS Activity in CAV1 Knockout Mouse Eyes.

Although CAV1 KO mice had elevated IOP and decreased outflow facility, CAV1 deficiency (and possibly the loss of CAV2) resulted in increased eNOS activity.

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice.

NOS3 KO mice have elevated IOP, which is likely the result of reduced pressure-dependent drainage.