Lenaers Guy

Nicotinamide Deficiency in Primary Open-Angle Glaucoma.

Glaucoma is associated with lower plasmatic nicotinamide levels, compared to controls, suggesting that nicotinamide supplementation might become a future therapeutic strategy. Further studies are needed, in larger cohorts, to confirm these preliminary findings.

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

Our results highlight a systemic and age-related mitochondrial defect in the pathogenesis of POAG.

A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines.

We identified a significant metabolomic signature in the plasma of individuals with XFS.