Gisèle Li

Age-Related Eye Disease and Cognitive Function: The Search for Mediators.

People with glaucoma showed lower scores on cognitive tests that may depend on verbal working memory and encoding.

A Systematic Review and Meta-analysis of Systemic Antihypertensive Medications With Intraocular Pressure and Glaucoma.

Systemic antihypertensive medications have heterogeneous effects on glaucoma and IOP. Clinicians should be aware that systemic antihypertensive medications may mask elevated IOP or positively or negatively affect the risk of glaucoma.

Alcohol Consumption, Genetic Risk, and Intraocular Pressure and Glaucoma: The Canadian Longitudinal Study on Aging.

Alcohol frequency and total alcohol intake were associated with elevated IOP but not with glaucoma. The PRS modified the association between total alcohol intake and IOP. Findings should be confirmed in longitudinal analyses.

Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging.

Evidence increasingly points to the APOE ε4 allele having protective benefits against glaucoma, but this association was limited to those without systemic hypertension.

Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging.

Our results suggest that the KIBRA and PDE7A/MTFR1 genes may modify the association between eye disease and cognitive function.

Reply to Comment on A systematic review and meta-analysis of systemic antihypertensive medications with intraocular pressure and glaucoma.

Re: Owsley et al.: Commentary: Cautionary remarks on linking cognitive impairment to glaucoma and age-related macular degeneration (Ophthalmology. 2020;127:667).