Karl Mercieca

Clinical outcomes of the PAUL® glaucoma implant: One-year results.

PGI surgery is an effective procedure for reducing IOP and pressure-lowering therapy. An intraluminal prolene stent impedes hypotony in the early postoperative phase and enables further IOP lowering without additional interventions during the postoperative course.

Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Müller Cell Secretion.

An age-dependent decrease in CRYAB, CRYBB2, and CRYGB abundance is found going along with increased RGC loss.

Trabeculectomy bleb needling and antimetabolite administration practices in the UK: a glaucoma specialist national survey.

There is a significantly wide variety of current practices for antimetabolite administration and bleb needling within the UK and Ireland.

Risk Factors for Failure in Glaucoma Patients Undergoing Microshunt Implantation.

This study identified risk factors for Microshunt failure, highlighting the importance of high intraoperative MMC dose and careful patient selection to optimize surgical success.

Trans-conjunctival Erosion of a Novel SIBS Microshunt After Revision Surgery Using Mitomycin C.

This article describes the first reported case of trans-conjunctival Preserflo microshunt erosion after revision surgery augmented with mitomycin C.

Elevated intraocular pressure induces neuron-specific β-III-tubulin expression in non-neuronal vascular cells.

The unprecedented regulation of neuron-specific β-III-tubulin in pericytes and endothelial cells is likely associated with a role of the retinal vasculature in the IOP-induced development and manifestation of glaucomatous degenerative optic nerve response.

Mitochondrial Markers in Aging and Primary Open-Angle Glaucoma.

This review focuses on recent progress in understanding the role of mitochondrial markers in the context of mitochondrial dysfunction in glaucoma and discussing new therapeutic approaches to modulate mitochondrial function and potentially lead to improved…

Two-Year Clinical Outcomes of the PAUL Glaucoma Implant in White Patients With Refractory Glaucoma.

PGI surgery is an effective procedure for reducing IOP and pressure-lowering therapy.

A Comparison of Deep Sclerectomy Trainer Versus Trainee Outcomes.

IOP outcomes of DS and phaco-DS were not adversely affected if fellows performed surgery, whether under supervision or independently.

Influence of a Prostaglandin F2α Analogue on Corneal Hysteresis and Expression of Extracellular Matrix Metalloproteinases 3 and 9.

PGAs alter biomechanical structures by directly upregulating MMP-3 and -9, and the increase in CH is dependent on the level of IOP. Therefore, PGAs may have a greater effect when baseline IOP is higher.

Transconjunctival Compression Sutures for an Overfiltering Bleb Following Subconjunctival Gel Stent Insertion for Glaucoma.

The complication was successfully treated with a modified transconjunctival bleb compression suture technique.

Five-Year Clinical Outcomes of Inferior Quadrant Trabectome Surgery for Open Angle Glaucoma.

Trabectome surgery is a safe and relatively effective procedure for lowering IOP, but most patients still need IOP-lowering agents, and a considerable proportion may need additional glaucoma surgery within a relatively short time.

Sonographic bleb visualisation after PAUL glaucoma implant surgery.

Sonography is a suitable modality to evaluate bleb characteristics after PGI implantation.

Anterior segment OCT for imaging PAULglaucoma implant patch grafts: a useful method for follow-up and risk management.

Pericardial patch grafts tend to thin over time which can be assessed by AS-OCT, the latter proving to be a useful method to follow-up patients who undergo patch graft implantation during PGI surgery.

Pachymeter Use and Disinfection Practice in the United Kingdom: A National Survey.

There is a large variation in methods and duration of tip disinfection with only a few units following the Royal College of Ophthalmologists (RCOphth) guidelines on pachymeter disinfection.

Clinical outcomes of the PAUL glaucoma implant in primary open-angle and pseudoexfoliative glaucoma eyes after failed glaucoma surgeries.

In conclusion, the PGI demonstrated significant IOP reduction and decreased need for medication in both POAG and PEXG patients, with no major differences between the two groups at 12 months.

Clinical outcomes of the PAUL® Glaucoma implant for refractory glaucoma: three-year results.

PGI surgery effectively reduces IOP and medication burden in refractory glaucoma, with sustained efficacy over three years. The intraluminal Prolene stent enables further non-invasive IOP reduction postoperatively.

A Prospective, Real-World, Multicenter Study to Support the Role of Ab-Interno Canaloplasty in Glaucoma Management.

In real-world clinical practice, iTrack canaloplasty significantly reduced IOP and medication burden with a favorable safety profile when performed alone or with phacoemulsification and in diverse glaucoma populations.

Clinical outcomes of the EyeWatch system: three-year results.

Most device adjustments occurred within the first postoperative year, after which IOP remained stable without further intervention.

Clinical outcomes of the PAUL Glaucoma implant for neovascular glaucoma.

The PGI demonstrates significant IOP reduction in NVG, with sustained success at higher IOP thresholds. However, maintaining very low IOP levels remains challenging.

Comparing the use of Tutopatch® pericardium with Tutoplast® fascia lata in the context of PAUL® glaucoma implant surgery: an anterior segment OCT study.

This study shows that AS-OCT is a useful method for comparing different patch materials after PGI surgery.

Preoperative predictive thresholds for successful canaloplasty in glaucoma patients.

In patients with preoperative IOPs of ≤ 36.9 mmHg or 27.1 mmHg, canaloplasty is likely to be an effective and safe procedure to obtain target pressures ≤ 18 mmHg with or without IOP-lowering eye drops, respectively.

Clinical Outcomes of Intraluminal Stent Removal After PAUL Glaucoma Implant Surgery.

Removal of the prolene stent following PGI surgery effectively lowers IOP in the short term, with a moderate increase in IOP and need for pressure-lowering therapy over time.

Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multicenter Study.

All 3 NPGS provide sustained IOP reduction, but DS and CP provide better success rates and IOP control.

Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: A Systematic Review and Meta-Analysis.

Intraoperative sub-Tenon MMC injection is noninferior to intraoperative MMC-soaked sponges in trabeculectomy surgery in terms of surgical failure and IOP control, with a reduced number of medications, improved bleb morphology, and similar safety profile.

Anterior Corneal Folds in Postoperative Hypotony Following Glaucoma Drainage Surgery.

Management of Descemet's membrane haemorrhage after canaloplasty.

Referral for glaucoma surgery and types of surgery in different European regions in 2025, the EURACCUR study.

European glaucoma care shows marked regional differences in surgical practices and referral timeliness. Frequent late referrals are associated with advanced disease, highlighting a need for improved early intervention to prevent vision loss.

Ocular drug delivery systems: glaucoma patient perceptions from a German university hospital eye clinic.

ODD for the treatment of glaucoma were broadly deemed acceptable by patients in this study.

European Glaucoma Society - A guide on surgical innovation for glaucoma.

This guide from the European Glaucoma Society offers crucial advice on surgical innovation for glaucoma, emphasizing rigorous evaluation and patient safety. It promotes responsible development and adoption of new surgical techniques to improve patient outcomes.

Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: True Risk Factors or Arbitrary Definition?