Milea Dan

Nicotinamide Deficiency in Primary Open-Angle Glaucoma.

Glaucoma is associated with lower plasmatic nicotinamide levels, compared to controls, suggesting that nicotinamide supplementation might become a future therapeutic strategy. Further studies are needed, in larger cohorts, to confirm these preliminary findings.

Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements.

Following eye movements, our models predicted high optic nerve sheath traction forces of the same order of magnitude as extraocular muscle forces.

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency.

Our results highlight a systemic and age-related mitochondrial defect in the pathogenesis of POAG.

Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma.

Patients with early-stage POAG exhibit reduced pupillary responses to moderate and high irradiances of blue and red lights.

Effect of acute intraocular pressure elevation on the minimum rim width in normal, ocular hypertensive and glaucoma eyes.

Acute IOP elevation leads to compression of the nerve fibre layers of neuroretinal rim in glaucoma subjects only without changing ONH size.

Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma.

Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements.

A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines.

We identified a significant metabolomic signature in the plasma of individuals with XFS.

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects.

In this sample, subjects with glaucoma exhibited tauter optic nerves and more protruding eye globes compared with normal eyes. This may impact optic nerve head deformations in anatomically predisposed patients.

Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study.

Highly myopic eyes had considerable prevalences of NGON and GLON/GON, usually higher than 20% and 10%, respectively.

Ocular and General Determinants of Intraocular Pressure: The Two-Continent Eye Study.

Among numerous ocular and systemic factors influencing IOP readings (with a relative low correlation coefficient), corneal curvature radius was one of the main ocular determinants.

Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia.

PLRs to ramping-up light stimuli are unaltered in highly myopic eyes without other diagnosed ocular conditions.

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.

Our models predicted high ONH strains during eye movements, which were aggravated with stiffer optic nerve sheaths.

Flavonoids and glaucoma: revisiting therapies from the past.

Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity.

In glaucomatous eyes, reduced pupillary responses to high-irradiance blue light were associated with greater visual field loss and optic disc cupping.