Perera Shamira

DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images.

DeshadowGAN significantly corrected blood vessel shadows in OCT images of the ONH.

Describing the Structural Phenotype of the Glaucomatous Optic Nerve Head Using Artificial Intelligence.

Our network was able to identify novel biomarkers of the ONH for glaucoma diagnosis. Specifically, the structural features identified by our algorithm were found to be related to clinical observations of glaucoma.

Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease.

In this study, 2 of 8 PACG-associated loci were associated significantly with PACS status, the earliest stage in the angle-closure glaucoma disease course.

Social, health and ocular factors associated with primary open-angle glaucoma amongst Chinese Singaporeans.

Older age, family history of glaucoma, higher intraocular pressure, thinner central corneal thickness and myopia were significantly associated with primary open-angle glaucoma amongst Chinese Singaporeans.

Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci for Estimating Angle Closure Disease Severity.

Our results show that EPDR1 is associated significantly with severe PACG, suggesting that it may predispose patients to more aggressive disease development.

The three-dimensional structural configuration of the central retinal vessel trunk and branches as a glaucoma biomarker.

Our work demonstrated that the diagnostic power of the CRVT&B is superior to that of a gold-standard glaucoma parameter, that is, RNFL thickness.

Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma.

Although significant on their own, the incorporation of genetic data in the context of anterior segment imaging parameters like ACD provided only a marginal improvement of PACG detection.

Association of iris crypts with acute primary angle closure.

Our study comprising Asian eyes with angle closure suggests that the presence of a higher crypt grading may be protective for APAC.

Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Patients with Normal- and High-Tension Glaucoma.

We found significant negative associations between IOP-induced ONH strains and retinal sensitivity in a relatively large glaucoma cohort.

Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains.

Our study has shown that the integration of biomechanical data can significantly improve the accuracy of visual field loss predictions and highlights the importance of the biomechanics-function relationship in glaucoma.

Shared Cared for Stable Glaucoma Patients: Economic Benefits and Patient-centered Outcomes of a Feasibility Trial.

Managing stable glaucoma patients at a primary care setting is a cost saving, safe, and effective shared care while enhancing professional collaboration between hospital and community settings.

Efficiency, Precision, Validity, and Reliability of GlauCAT-Asian Computerized Adaptive Tests in Measuring Glaucoma-Related Quality of Life.

GlauCAT-Asian provides efficient, precise, accurate, valid, and reliable measurement of the patient-centered impact of glaucoma.

AI to Identify Strain-Sensitive Regions of the Optic Nerve Head Linked to Functional Loss in Glaucoma.

ONH strain enhances classification of glaucomatous VF loss patterns. The neuroretinal rim, rather than the LC, was most critical, suggesting rim strain may play a dominant role in axonal injury and functional loss.

Subtypes of primary angle closure disease based on age-independent anterior segment optical coherence tomography parameters.

We identified 3 subgroups of angle closure eyes, each characterised by distinct structural components based on ASOCT.

Does Bevacizumab Improve Outcomes After Ahmed Glaucoma Valve Implantation for Refractory Glaucoma?: A Meta-Analysis.

Published studies investigating the role of adjunctive bevacizumab show a strong trend to improve outcomes but contain a relatively small number of participants.

Novel hyperparallel optical coherence tomography for angle closure assessment: comparison with swept-source OCT and gonioscopy.

HP-OCT showed excellent reproducibility for angle closure assessment and good agreement with SS-OCT and gonioscopy.

Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia.

PLRs to ramping-up light stimuli are unaltered in highly myopic eyes without other diagnosed ocular conditions.

Anterior Chamber Angle and Intraocular Pressure Changes After Phacoemulsification: A Comparison Between Eyes With Closed-angle and Open-angle Glaucoma.

Angle opening postphacoemulsification was considerable in all eyes. A similar IOP reduction after phacoemulsification was observed in all eyes regardless of angle status.

A Survey on the Preference of Sustained Glaucoma Drug Delivery Systems by Singaporean Chinese Patients: A Comparison Between Subconjunctival, Intracameral, and Punctal Plug Routes.

Sustained drug delivery for the medical treatment of glaucoma is an acceptable alternative to daily eye drop administration by most Singaporean Chinese individuals in this study.