Pfeiffer Norbert

Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy.

No statistically significant differences were found between trabeculectomy, XEN45gelstent implantation and PreserfloMicroShunt implantation regarding surgical success after 6 months.

Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo.

IOP elevation caused significant RGC loss (P < 0.001); 3-mercaptosulfurtransferase, an H2S producing enzyme, showed a 3-fold upregulation within the retina after IOP elevation.

Bruch's Membrane Opening-Minimum Rim Width Assessment With Spectral-Domain Optical Coherence Tomography Performs Better Than Confocal Scanning Laser Ophthalmoscopy in Discriminating Early Glaucoma Patients From Control Subjects.

The BMO-MRW assessment with SD-OCT performed well in discriminating early glaucoma patients from control subjects and had a better performance than CSLO. The diagnostic classifications of HRT3 and Spectralis OCT may reach good agreement.

Peripapillary Retinal Nerve Fiber Layer Profile in Relation to Refractive Error and Axial Length: Results From the Gutenberg Health Study.

The pRNFL profiles are related to individual ocular and systemic parameters.

Intraocular Pressure and Its Relation to Ocular Geometry: Results From the Gutenberg Health Study.

IOP values are related to ocular geometry, as shown in this population-based study on Caucasian subjects.

Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model.

In conclusion, these results provide further lines of evidence that substantial molecular changes occur at the onset of the disease, identifying potential key players, which might be useful as biomarkers for diagnostics and development of…

Suprachoroidal Bleeding After XEN Gel Implantation.

Minimally invasive glaucoma surgery is developed to provide a safer and less-invasive option to reduce IOP in glaucoma patients compared with trabeculectomy.

Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium.

We identified a potentially harmful association between use of CCBs and glaucoma prevalence.

Cardiovascular medication and intraocular pressure: results from the Gutenberg Health Study.

None of the cardiovascular medications, in particular systemic β-blocking agents, showed an association with IOP in non-glaucoma subjects.

Course of serum autoantibodies in patients after acute angle-closure glaucoma attack.

With this autoantibodies profiling approach, we were able to detect autoimmune reactivities in sera of patients without former indication for glaucomatous damage after rise of IOP due to AACG attack.

Optic Nerve Head Morphology in Adults Born Extreme, Very, and Moderate Preterm With and Without Retinopathy of Prematurity: Results From the Gutenberg Prematurity Eye Study.

The present study provides evidence that individuals born extremely preterm have increased VCDR in adulthood.

Optical Coherence Tomography Angiography of Optic Disc in Eyes With Primary Open-angle Glaucoma and Normal-tension Glaucoma.

Overall, glaucomatous eyes had lower peripapillary VD compared with normal and OHT eyes. There is a strong relationship between the peripapillary structure of RNFL and its vasculature.

Catheter-assisted 360-Degree Trabeculotomy for Congenital Glaucoma.

Ab externo catheter-assisted 360-degree trabeculotomy controls IOP in a majority of patients with congenital glaucoma after a single operation.

Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood-Results from a Population-Based Study.

Our data show that there is a weak relationship between birth weight and pRNFL thickness in adulthood.

XEN-augmented Baerveldt Implantation for Refractory Childhood Glaucoma: A Retrospective Case Series.

XEN-augmented Baerveldt implantation was used for refractory pediatric glaucoma in which conventional surgery had already failed.

Noninferiority of Preservative-free Versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients With Open-angle Glaucoma or Ocular Hypertension.

Preservative-free latanoprost-timolol fixed combination T2347 showed noninferior efficacy compared with the preserved comparator and was well tolerated.

A European Study of the Performance and Safety of MINIject in Patients With Medically Uncontrolled Open-angle Glaucoma (STAR-II).

Ab-interno supraciliary surgical implantation using MINIject DO627 in a stand-alone procedure significantly lowers IOP by 40% at the 6-month follow-up, while reducing the need for IOP-lowering medication.

Outcomes of Open Bleb Revision After PreserFlo MicroShunt Failure in Patients With Glaucoma.

At 12 months, open revision with MMC for bleb fibrosis after failed PreserFlo implantation effectively and safely reduced IOP with a similar medication burden.

Results of an Adaptive Surgical Approach for Managing Late Onset Hypotony After Trabeculectomy With Mitomycin C.

In patients with hypotony an adaptive approach of bleb management shows good results both in terms of IOP control and improvement in VA.

Three-Year Results of Hydrus Microstent with Phacoemulsification.

Prevalence of Glaucoma in Europe and Projections to 2050: Findings from the European Eye Epidemiology Consortium.

The current and future burden of glaucoma in Europe may be substantially higher than previously estimated, with a considerable proportion of disease in the general population remaining undetected.

Results of childhood glaucoma surgery over a long-term period.

We found very promising surgical results in our childhood glaucoma patient group. Surgical success in both congenital and secondary glaucoma was high.

Peripheral corneal thickness and associated factors - results from the population-based German Gutenberg Health Study.

The results of the present study suggest that several general and ocular parameters are associated with peripheral corneal thickness.

Change of Intraocular Pressure Over 5 Years and its Relationship to Cardiovascular Parameters: Results From the Gutenberg Health Study.

This population-based study found a relationship between IOP change over 5 years and BMI and systolic blood pressure change, respectively. These findings suggest the importance of monitoring cardiovascular risk factors in IOP management.

Suture Removal After Trabeculectomy With Fornix-based Conjunctival Flap Leads to Faster Visual Recovery but Not Reduced Astigmatism.

Removal of the conjunctival suture in trabeculectomy with a fornix-based conjunctival flap leads to a faster rehabilitation of visual acuity but does not significantly affect corneal astigmatism or IOP.

Urrets-Zavalia Syndrome After Combined Trabeculotomy-Trabeculectomy Surgery.

However, postoperatively, he experienced a long-lasting hypotony with the need of 2 revision surgeries and 2 short episodes of high-intraocular pressure. He developed a fixed dilated pupil over time.

Spontaneous Resolution of Delayed Suprachoroidal Hemorrhage in the Single Eye Following Needling in Congenital Glaucoma.

After 2 months, choroidal swelling had completely resolved, best-corrected visual acuity was 20/50, and intraocular pressure was 11 mm Hg.

Characteristics and Treatment Outcomes of Hypotony Maculopathy Postglaucoma Filtering Surgery: An Optical Coherence Tomography-Based Study.

Bleb revision procedures for HM following glaucoma filtering surgery show promising outcomes, including notable improvements in visual acuity and IOP.

The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.

Higher GPRS is associated with glaucoma prevalence, higher IOP and thinner pRNFL in two population-based studies in Germany. These associations were particularly seen in older participants.

Altered Neuroretinal Tissue in Childhood Cancer Survivors: Data From the German CVSS Study.

The pRNFL is thinner in CCS with most common tumor entities, except lymphoma and germ cell tumors. Cranial radiation and platin derivates had negative effects on the pRNFL thickness.

Mid-term real world outcomes of the HydrusMicrostent in open angle glaucoma.

This study underlines the effectiveness and the safety of the HydrusMicrostent in an elective setting, but it also demonstrates certain limits and risk factors of this procedure.

Distribution of Anterior Chamber Angle Width and Correlation With Age, Refraction, and Anterior Chamber Depth-The Gutenberg Health Study.

A total of 3014 subjects (48% female) with a mean age of 58.6 ± 10.4 years were included in this study.

Comparison of Laser Scanning Diagnostic Devices for Early Glaucoma Detection.

FD-OCT and SLP have a similarly good diagnostic ability to distinguish between early glaucoma and healthy subjects. The diagnostic accuracy of CSLO was comparable with SLP and marginally lower compared with FD-OCT.

A Randomized Trial of a Schlemm's Canal Microstent with Phacoemulsification for Reducing Intraocular Pressure in Open-Angle Glaucoma.

Intraocular pressure was clinically and statistically significantly lower at 2 years in the Hydrus plus CS group compared with the CS alone group, with no differences in safety.

Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study.

Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of OAG among the EGPS participants.

The size of subconjunctival preparation does not influence the outcome of trabeculectomy with mitomycin C.

There were no significant differences between study groups in mean IOP reduction, change in BCVA, or number of applied 5-FU and SL at 1-year follow-up.