Prokosch Verena

The novel role of lymphatic vessels in the pathogenesis of ocular diseases.

The preclinical data presented here outline novel therapeutic concepts for promoting transplant survival, inhibiting metastasis of ocular tumors, reducing inflammation of the ocular surface, and treating glaucoma.

Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model.

In conclusion, these results provide further lines of evidence that substantial molecular changes occur at the onset of the disease, identifying potential key players, which might be useful as biomarkers for diagnostics and development of…

Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Müller Cell Secretion.

An age-dependent decrease in CRYAB, CRYBB2, and CRYGB abundance is found going along with increased RGC loss.

Elevated intraocular pressure induces neuron-specific β-III-tubulin expression in non-neuronal vascular cells.

The unprecedented regulation of neuron-specific β-III-tubulin in pericytes and endothelial cells is likely associated with a role of the retinal vasculature in the IOP-induced development and manifestation of glaucomatous degenerative optic nerve response.

Mitochondrial Markers in Aging and Primary Open-Angle Glaucoma.

This review focuses on recent progress in understanding the role of mitochondrial markers in the context of mitochondrial dysfunction in glaucoma and discussing new therapeutic approaches to modulate mitochondrial function and potentially lead to improved…

Factors influencing the outcomes of trabeculectomy, conventional canaloplasty, and mitomycin C augmented canaloplasty.

TE, cCP, and mCP led to a significant reduction in IOP and IOP-lowering eye drops during 18 months of follow-up.

Anterior segment OCT for imaging PAULglaucoma implant patch grafts: a useful method for follow-up and risk management.

Pericardial patch grafts tend to thin over time which can be assessed by AS-OCT, the latter proving to be a useful method to follow-up patients who undergo patch graft implantation during PGI surgery.

Comparing the use of Tutopatch® pericardium with Tutoplast® fascia lata in the context of PAUL® glaucoma implant surgery: an anterior segment OCT study.

This study shows that AS-OCT is a useful method for comparing different patch materials after PGI surgery.

Preoperative predictive thresholds for successful canaloplasty in glaucoma patients.

In patients with preoperative IOPs of ≤ 36.9 mmHg or 27.1 mmHg, canaloplasty is likely to be an effective and safe procedure to obtain target pressures ≤ 18 mmHg with or without IOP-lowering eye drops, respectively.

Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multicenter Study.

All 3 NPGS provide sustained IOP reduction, but DS and CP provide better success rates and IOP control.

European Glaucoma Society research priorities for glaucoma care.

We have developed a list of priorities for glaucoma research involving clinicians and patients from different European countries that will help guide research efforts and investment.

Mid-term real world outcomes of the HydrusMicrostent in open angle glaucoma.

This study underlines the effectiveness and the safety of the HydrusMicrostent in an elective setting, but it also demonstrates certain limits and risk factors of this procedure.