Susan E. Quaggin

SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma.

We provide further evidence for PCG caused by TEK haploinsufficiency, affirm autosomal dominant inheritance in two pedigrees, and propose SVEP1 as a modifier of TEK expression during SC development, affecting disease penetrance and severity.

Angiopoietin-1 Knockout Mice as a Genetic Model of Open-Angle Glaucoma.

These findings highlight the potential ofconditional knockout mice as a valuable new glaucoma model.