Quigley Harry

Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes.

The lamina can move either anteriorly or posteriorly with IOP decrease, with greater displacement at lower IOP. Glaucoma eyes and regions within glaucoma eyes associated with greater glaucoma damage exhibited smaller responses.

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma.

ROCK inhibitors reduce TGFβ-induced myofibroblast transdifferentiation and glaucoma-induced scleral cell proliferation.

IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors.

The proteins that translate mechanical stimuli into molecular signals act as band-pass filters - sensing some stimuli while ignoring others - and cellular responses to stimuli can differ based on cell type and differentiation state.

The Effect of Change in Intraocular Pressure on Choroidal Structure in Glaucomatous Eyes.

The increase in choroidal thickness at lower IOP is associated with approximately equal increases in its intravascular and extravascular compartments.

Long-Term Functional Outcomes of Glaucoma Tube Shunt Revision Surgery.

The estimated rate of failure of tube shunt revision is 75% by 5 years, most often because of a need for further surgery.

Validation of 16S rRNA Gene Sequencing of the Periocular Microbiome and Lack of Alteration by Topical Eyedrops.

16S rRNA analysis correlates well with conventional culture results for the eyelid microbiome, with results from neither technique demonstrating an association of microbiome composition and eyedrop use.

Prophylactic Antibiotics after Glaucoma Surgery: Where Is the Evidence?

Iris volume change with physiologic mydriasis to identify development of angle closure: the Zhongshan Angle Closure Prevention Trial.

A smaller change in ΔVOL is an additive risk factor to identify eyes more likely to develop angle closure disease.