Ramulu Pradeep

Artificial Intelligence Classification of Central Visual Field Patterns in Glaucoma.

We quantified central VF patterns in glaucoma, which were used to improve the prediction of central VF worsening compared with using only global indices.

Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence.

In this study, central VF loss in end-stage glaucoma was found to exhibit characteristic patterns that might be associated with different subtypes.

Beyond intraocular pressure: Optimizing patient-reported outcomes in glaucoma.

We provide a comprehensive, albeit non-systematic, critique of the psychometric properties, limitations, and recent advances of currently available glaucoma-specific PCOMs and PROMs.

Corneal Edema and Keratoplasty: Risk Factors in Eyes With Previous Glaucoma Drainage Devices.

The risk of postoperative corneal decompensation is persistent over time. Patients receiving GDDs, particularly those with advanced age, preexisting corneal pathology, and postoperative complications, should be counseled regarding their increased risk for corneal decompensation.

Evidence-Based Criteria for Determining Peripapillary OCT Reliability.

Signal strength decreases down to 3 have relatively mild impacts on OCT reliability.

Predicting Global Test-Retest Variability of Visual Fields in Glaucoma.

Inclusion of archetype VF loss patterns and TD values based on first VF improved the prediction of the global test-retest variability than using traditional global VF indices alone.

Cataract Surgery Lowers Intraocular Pressure and Medication Use in the Medication Group of the Ocular Hypertension Treatment Study.

Cataract surgery in patients with ocular hypertension produced sustained reductions in the average number of ocular hypotensive medications and transient reductions in IOP.

Comparing the Accuracy of Peripapillary OCT Scans and Visual Fields to Detect Glaucoma Worsening.

More frequent OCT scans and VF tests are needed to improve the accuracy of diagnosing glaucoma worsening.

Forecasting Risk of Future Rapid Glaucoma Worsening Using Early Visual Field, OCT, and Clinical Data.

Deep learning models can forecast future rapid glaucoma worsening with modest to high performance when trained using data from early in the disease course.

Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening.

To diagnose RNFL worsening more accurately, the number of OCT scans must be increased compared with current clinical practice. A clustered measurement strategy reduces the number of scans required compared with evenly spacing measurements.

The Effect of Achieving Target Intraocular Pressure on Visual Field Worsening.

In treated patients, failing to achieve target IOP was associated with more rapid VF worsening. Eyes with moderate glaucoma experienced the greatest VF worsening from failing to achieve target IOP.

Short-Term Outcomes of Hydrus Microstent With and Without Additional Canaloplasty During Cataract Surgery.

Microstent combined with canaloplasty resulted in a significantly higher rate of medication-free status compared with microstent alone through 6 months.

The Association Between Intraocular Pressure and Visual Field Worsening in Treated Glaucoma Patients.

IOP remained associated with VF worsening in eyes with more advanced glaucoma throughout the IOP range but was only associated with VF worsening in eyes with less severe glaucoma at higher IOP.

The Impact of Social Vulnerability on Structural and Functional Glaucoma Severity, Worsening, and Variability.

Increased SVI score is associated with worse functional (VF) loss at baseline, higher rates of structural (OCT) worsening over time, higher VF variability, and a greater effect of IOP on RNFL loss.

Validation of 16S rRNA Gene Sequencing of the Periocular Microbiome and Lack of Alteration by Topical Eyedrops.

16S rRNA analysis correlates well with conventional culture results for the eyelid microbiome, with results from neither technique demonstrating an association of microbiome composition and eyedrop use.

Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility.

VF patterns of the worse eye are predictive of VF defects in the better eye.

Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status.

These findings support the need for further studies to confirm the association between POAG diagnosis and a decrease in mental health score and to develop strategies to inform patients about their POAG diagnosis without producing…

Improving Visual Field Forecasting by Correcting for the Effects of Poor Visual Field Reliability.

Including all VFs in the trend estimation has more predictive power for future reliable VFs than excluding unreliable VFs. Correcting for VF reliability further improves model accuracy.

Opportunities for Improving Glaucoma Clinical Trials via Deep Learning-Based Identification of Patients with Low Visual Field Variability.

Deep learning models can forecast eyes with low VF variability using data from a single baseline clinical visit.

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study.

The 95% limits for average RNFL and CDR were within 12.7 microns and 0.2 units, respectively, between eyes.

Quality of Life and Primary Open-Angle Glaucoma in the Ocular Hypertension Treatment Study.

In this cross-sectional study, among the surviving participants of OHTS who completed the 20-year follow-up examination, those participants who developed preperimetric POAG but no glaucomatous VF loss did not report lower VFQoL compared with participants who did not develop POAG.