Bronwyn Ridge

Cardiovascular Disease Predicts Structural and Functional Progression in Early Glaucoma.

Cardiovascular disease is an important risk factor for glaucoma progression.

Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts.

Body mass index correlated with longitudinal and cross-sectional glaucomatous outcomes. This supports previous work illustrating a correlation between BMI and glaucoma.

Macular Ganglion Cell-Inner Plexiform Layer Loss Precedes Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma with Lower Intraocular Pressure.

Clinical features, particularly pretreatment IOP, influence whether structural glaucoma progression is detected earlier with mGCIPL or pRNFL imaging.

Attitudes Towards Polygenic Risk Testing in Individuals with Glaucoma.

These findings will help to facilitate the clinical implementation of PRS testing for glaucoma to reduce irreversible vision loss.

High Polygenic Risk Is Associated with Earlier Initiation and Escalation of Treatment in Early Primary Open-Angle Glaucoma.

This study demonstrated novel associations between glaucoma polygenic risk and risk of commencement or escalation of IOP-lowering therapy, building on previous work highlighting the potential clinical usefulness of genetic risk stratification in glaucoma.

Quality of Life in Adults with Childhood Glaucoma: An Interview Study.

Childhood glaucoma poses a substantial impact to the emotional well-being of adults with the condition, which is mediated by the use of coping strategies.

Effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: A prospective multi-site study.

Cataract surgery has a confirmed effect in reducing IOP in a "real world" setting of early glaucoma patients.

Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.

Our results show strong interest in genetic risk assessment for glaucoma among unaffected individuals in Australia.

Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study.

These results highlight the potential neuroprotective benefits of exercise on the human retina.

Quantification of localised vascular wedge-shaped defects in glaucoma.

Vascular wedge defects are present at all POAG stages even before functional change and are strongly concordant with focal RNFL loss.

The Caregiver Experience in Childhood Glaucoma: An Interview Study.

Childhood glaucoma poses a substantial threat to a caregiver's psychosocial well-being.

Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma.

This study demonstrated that female sex is a risk factor for developing advanced NTG.

Occurrence of CYP1B1 Mutations in Juvenile Open-Angle Glaucoma With Advanced Visual Field Loss.

Patients with advanced JOAG based on visual field loss had enrichment of CYP1B1 pathogenic variants and a more severe phenotype compared with unaffected controls and patients with nonadvanced JOAG.

Severe intraocular pressure response to periocular or intravitreal steroid treatment in Australia and New Zealand: data from the Australian and New Zealand Ophthalmic Surveillance Unit.

Severe intraocular pressure elevation following intravitreal or periocular corticosteroid injection can occur in the absence of risk factors such as personal and family history of glaucoma. The severe intraocular pressure elevation may ultimately require trabeculectomy.

Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma.

We report the presence of TBK1 copy number variations in our Australian normal-tension glaucoma cohort, including the first example of more than 1 extra copy of this gene in glaucoma patients (gene triplication).