Schnichels Sven

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina.

In many cases, a replacement of in vivo research will mean that several different in vitro models are used in conjunction, for instance to analyze and validate causative molecular pathways.

Oxidative stress-induced retinal damage is prevented by mild hypothermia in an ex vivo model of cultivated porcine retinas.

Reduced apoptosis rates through hypothermia led to a preservation of RGCs (P < .001).

α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model.

This rabbit GFS study indicates that inhibition of α5β1-integrin by the novel α5β1-integrin antagonist CLT-28643 significantly improved the outcome. The effect of a single intro-operative application of CLT-28643 seems to be inferior to 0.04% MMC.

TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells.

The expression of TRPP2 and the primary cilium in the CB may indicate a possible role, such as the sensing of hydrostatic pressure, for the regulation of IOP.