Sigal Ian A

Scleral structure and biomechanics.

Studies into alterations of scleral structure and biomechanics in myopia and glaucoma are presented, and their results reconciled with associated findings on changes in the ageing eye.

Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.

Models predict that IOP and CSFP are the top and sixth most influential factors on ONH biomechanics.

Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers.

Small, uniform crimp periods within the sheep LC and immediately adjacent PPS may indicate that these tissues are setup to prevent large or heterogeneous deformations that insult the neural tissues within the canal.

So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult.

Missing LC connective tissues can mitigate IOP-induced neural tissue insult, suggesting that the role of the LC connective tissues is more complex than simply fortifying against IOP.

Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility.

Thick prelaminar tissue was associated with impaired visualization of the LC. Healthy subjects generally had thicker prelaminar tissue, which potentially could create a selection bias against healthy eyes when comparing LC structures.

Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.

Increasing IOP acutely caused nonlinear LC deformations with an overall smaller effect postmortem than premortem.

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina.

Astrocyte morphology in the LC was characterized through multicolor DiOlistic labeling.

Pericytes in the optic nerve head.

ONH pericytes represent a promising but underexplored target for treating microvascular impairment in glaucoma.

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult.

Our approach allowed discerning axonal longitudinal and transverse mechanical insults, which are likely associated with different mechanisms of axonal damage.

Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina.

Insertions in the anterior LC were sparser, narrower, and more slanted than those in deeper LC (P values < 0.001).

Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury.

Optic nerve head neural rim tissue thinning exceeded peripapillary RNFL thinning in NHP EG.

Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk.

These findings results demonstrate the importance of considering the anatomical location of CRVT in the assessment of the LC, as there is a relationship between the distance from the CRVT and the LC microstructure, which…