Sun Xinghuai

Primary angle closure glaucoma: What we know and what we don't know.

New treatment strategies like adjusting the psychological status and balancing the sympathetic-parasympathetic nerve activity, and innovative medicines are needed to improve the prognosis of PACG.

Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study.

Even when IOP was normalized after the acute attack, the APAC eyes had a lower peripapillary retinal vessel density, which was correlated with the VF values.

Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography.

Retinal vessel density was significantly reduced in PACG eyes. The magnitude of this difference varied between the fundus areas, and was greater in the peripapillary area.

Morphologic Features of Crystalline Lens in Patients with Primary Angle Closure Disease Observed by CASIA 2 Optical Coherence Tomography.

Steep anterior curvature and decentration of the crystalline lens may be another anatomic characteristic of eyes with PACD.

White Matter Abnormalities and Correlation With Severity in Normal Tension Glaucoma: A Whole Brain Atlas-Based Diffusion Tensor Study.

Atlas-based DTI analysis was capable of indicating WM damage in the four regions associated with visual and visual-related functions in NTG patients, and it could also be used for investigating disease progression and pathologic changes.

Association of serum uric acid levels with primary open-angle glaucoma: a 5-year case-control study.

Primary open-angle glaucoma patients have lower UA levels; however, a negative association between UA levels and disease severity was evident in male patients.

ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway.

Regulation of aqueous humor outflow via the caveolin-1/endothelial NO synthase/NO pathway is a newly defined function of ABCA1 that is different from its traditional role in mediating cholesterol efflux.

Vision-related Quality of Life in Glaucoma Patients and its Correlations With Psychological Disturbances and Visual Function Indices.

Deterioration of vision impairment and visual field defects in addition to increased recognition of psychological disturbances reduce the VR-QoL of glaucoma patients significantly.

Association of Plasma Complement C3 Levels With Primary Angle-Closure Glaucoma in Older Women.

Older women with PACG have lower plasma C3 levels, which were further demonstrated to be negatively associated with PACG severity. These findings suggest the involvement of C3 in the pathomechanisms of PACG in older women.

Association Between 17-β-Estradiol and Interleukin-8 and Visual Field Progression in Postmenopausal Women with Primary Angle Closure Glaucoma.

Decreased E2 and increased IL-8 levels at baseline are significant predictors of VF progression in postmenopausal women with PACG.

Automatic Anterior Chamber Angle Classification Using Deep Learning System and Anterior Segment Optical Coherence Tomography Images.

The experimental results showed that the proposed method can achieve a high accuracy of anterior chamber angle classification using AS-OCT images, and could be of value in future practice.

What Are the Characteristics of Primary Angle Closure With Longer Axial Length?

Among 138 angle-closure patients, 15 (10.9%) patients had longer ALs, of which 11 (73.3%) were male.

Decreased Serum Levels of Complement C3 Reflect Complement System Dysregulation in Patients With Primary Open-angle Glaucoma: Results From a Pilot Study.

The POAG patients had decreased C3 levels, which were further negatively associated with POAG severity, suggesting the involvement of C3 in the pathomechanisms of POAG.

Association Between Ocular Biomechanics Measured With Corvis ST and Glaucoma Severity in Patients With Untreated Primary Open Angle Glaucoma.

NTG corneas are more deformable than healthy ones and HTG.

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation.

Mechanical strain affected the cell behaviors of HSFs. The different performance of cells from distinct regions may suggest familial linages of HSFs, probably induced by mechanical strain.

The Clinical Features and Genetic Spectrum of a Large Cohort of Chinese Patients With Vitelliform Macular Dystrophies.

This is the largest sample size study of Chinese vitelliform macular dystrophy patients.

Association of 24-Hour Intraocular Pressure Fluctuation With Corneal Hysteresis and Axial Length in Untreated Chinese Primary Open-Angle Glaucoma Patients.

This study revealed the association of 24-hour IOP fluctuation with office hour corneal biomechanical properties and AL in patients with POAG.

Energy Dose-Response in Selective Laser Trabeculoplasty: A Review.

The optimal energy level of SLT needed for IOP reduction has not yet been definitively established, with all reported pulse energies resulting in similar IOP reduction.

Metabolic Alterations Within the Primary Visual Cortex in Early Open-angle Glaucoma Patients: A Proton Magnetic Resonance Spectroscopy Study.

Abnormal metabolites were found in our study through proton magnetic resonance spectroscopy and could contribute to cortical plasticity of the primary visual cortex in early OAG patients.

Grooved Glaucoma Drainage Devices That Continuously Deliver Cyclosporine A Decrease Postsurgical Scar Formation in Rabbit Eyes.

Compared with the normal GDDs, G-GDDs with a CsA-PLGA coating inhibited postsurgical scar formation and improved the surgical success rate, and might represent an alternative to existing glaucoma filtration devices.

Changes of anterior segment parameters in primary angle closure with axial myopia: a retrospective study of 369 patients grouped by axial length.

Primary angle-closed diseases recognition through artificial intelligence-based anterior segment-optical coherence tomography imaging.

Deep learning classifiers effectively detect angle closure based on automated analysis of AS-OCT images.

Immediate Impact of Acute Elevation of Intraocular Pressure on Cortical Visual Motion Processing.

In contrast to human chronic glaucoma that may cause greater dysfunction in large-cell magnocellular than in small-cell parvocellular visual pathways, our direct measurement of cortical processing networks implies that the small X-cell pathway shows greater…

Outcomes of Filtering Surgery Versus Clear Lens Extraction in Young Patients With Angle-Closure Glaucoma.

This study highlights that the efficacy of clear lens extraction is comparable to that of filtering surgery in medically uncontrolled ACG in young patients, but clear lens extraction is safer, especially for young patients with…

Novel predictors for malignant glaucoma in primary angle-closure glaucoma patients.

PACG eyes with a shorter cilio-lenticular distance and a narrower ciliary body-to-vitreous zonule area are more likely to develop malignant glaucoma.

Quality of Life and Associated Factors in Chinese Glaucoma Patients.

QoL of glaucoma patients is primarily determined by clinical indices. Unemployment is also an important correlate of low QoL among glaucoma patients.

Association Between Corneal Biomechanics and 24-hour Intraocular Pressure Variation in Untreated Glaucoma.

In untreated glaucoma, greater corneal deformability correlates with reduced 24-hour intraocular pressure fluctuations. This suggests corneal biomechanics influence IOP stability, which is crucial for monitoring and managing glaucoma progression.

The correlation of anterior segment structures in primary congenital glaucoma by ultrasound biomicroscopy with disease severity and surgical outcomes.

UBM is a powerful technique to exam anterior segment structures in PCG. The anatomical features are associated with disease severity and surgical outcomes, providing essential clinical insights.

Twenty-four-hour pattern of intra-ocular pressure in untreated patients with primary open-angle glaucoma.

There was some regularity in the 24-hr IOP pattern in POAG, but different severities of GON and different subtypes might present different characteristics.

Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia.

The macular measurements had significantly better glaucoma detection abilities than the cpRNFL thickness in the high-myopia subjects in both RTVue-OCT and Cirrus HD-OCT, with no significant differences in the diagnostic ability between the two macular…

eNOS Activity in CAV1 Knockout Mouse Eyes.

Although CAV1 KO mice had elevated IOP and decreased outflow facility, CAV1 deficiency (and possibly the loss of CAV2) resulted in increased eNOS activity.

Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma.

Trabeculectomy results in a significant increase in the angle width in PACG. The increase in angle parameters was significantly related to the IOP changes.

Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population.

Our findings suggest that the genetic backgrounds of PACG and POAG might be different.

Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study.

Angiograms demonstrated a reduced disc flow index and vessel density in glaucoma, and this reduction was closely related to GCC thickness.

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice.

NOS3 KO mice have elevated IOP, which is likely the result of reduced pressure-dependent drainage.

A Novel Motion-on-Color Paradigm for Isolating Magnocellular Pathway Function in Preperimetric Glaucoma.

The motion-on-color paradigm revealed a loss of contrast sensitivity in the peripheral visual field in preperimetric glaucoma.

Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population.

Genetic variants in CDKN2B-AS1, SIX1/SIX6, and TMCO1 were associated with POAG in a Han Chinese population.

Re: Wang et al.: Quantitative measurements of the ciliary body in eyes with malignant glaucoma after trabeculectomy using ultrasound biomicroscopy (Ophthalmology 2014;121:862-9).

Anxiety and Depression are More Prevalent in Primary Angle Closure Glaucoma Than in Primary Open-Angle Glaucoma.

Significant differences were found between primary glaucoma patients and normal controls in psychiatric questionnaires, whereas the level of anxiety and depression was found to be significantly higher in PACG patients than in POAG patients and…