Virgili Gianni

Microcystoid Macular Changes in Association With Idiopathic Epiretinal Membranes in Eyes With and Without Glaucoma: Clinical Insights.

This study reports a high frequency of microcystoid macular changes in the inner nuclear layer in eyes with concomitant epiretinal membrane and glaucomatous optic neuropathy.

Relationship Between Acuity and Contrast Sensitivity: Differences Due to Eye Disease.

The quantitative relationship between VA and CS depends on the ocular pathology. CS appears to provide valuable complementary information to VA in the early detection of eye disease and when evaluating visual impairment.

Comparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases.

Although most review outcomes were reported in the trials, most trial outcomes were not reported in the reviews.

What Do We Really Know about the Effectiveness of Glaucoma Interventions?: An Overview of Systematic Reviews.

Most systematic reviews evaluating interventions for glaucoma are of poor reliability.

Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study.

RNFL thickness data of OCT can be used as a diagnostic test, but accuracy estimates remain moderate even in exploratory multivariable modelling of aiming to improve accuracy.

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success.

Hypotony failure criteria are highly heterogenous in the glaucoma literature, with few studies focusing on clinical manifestations.

Risk of Intraocular Pressure Increase With Intravitreal Injections of Vascular Endothelial Growth Factor Inhibitors: A Cohort Study.

This study found an increased risk of IOPi among nondiabetic patients with ranibizumab and bevacizumab compared with aflibercept. Future studies are needed to validate these findings.

Comparative efficacy and safety of preserved versus preservative-free beta-blockers in patients with glaucoma or ocular hypertension: a systematic review.

Although some measures of ocular surface health favoured preservative-free medications, more evidence is needed.

Adverse Effects and Safety in Glaucoma Patients: Agreement on Clinical Trial Outcomes for Reports on Eye Drops (ASGARD)-A Delphi Consensus Statement.

We propose a consensus-based series of outcomes and assessment methods to be used in clinical trials assessing adverse effects of antiglaucomatous eye drops.

Home-Based Perimetry for Glaucoma: Where Are We Now?

Several promising technologies designed for home-based perimetry have been reported.

Evaluation of Generic versus Original Prostaglandin Analogues in the Treatment of Glaucoma: A Systematic Review and Meta-Analysis.

Trials comparing original and generic PGAs did not show a clinically significant difference in IOP-lowering effect or tolerability.

Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates.

The criteria for defining high IOP failure in glaucoma surgery are highly heterogeneous in the current literature.

How Can We Quantify and Compare Harm in Surgical Trials?

Analysis of harm data in clinical trials needs further attention.

The Multifaceted Nongenetic Risk Factors for Primary Open-angle Glaucoma: An Overview of Systematic Reviews.

This article summarizes the current knowledge on risk factors for POAG from published SRs.

The quality of reporting on Glaucoma Surgical Innovations during Early Development Stages using IDEAL Guidelines: a Systematic Review.

Critical aspects of study design and reporting were frequently missing in early-phase surgical studies of glaucoma.

Adherence of glaucoma intervention studies to World Glaucoma Association guidelines.

Current literature shows poor adherence to WGA guidelines across both traditional and newer glaucoma surgeries, reflecting inadequate reporting and outdated recommendations.

Potential Harms of Posterior Chamber Phakic IOL: A Systematic Review and Meta-Analysis of Complication Incidence.

PCPIOL implantation is associated with a low incidence of complications, and vision-threatening events appear to be very rare.

Patient preferences for adverse effects of intraocular pressure-lowering eye drops. Results from a Danish large-scale discrete choice experiment: These adverse effects matter to the patients.

This study provides novel insight into patients' preferences for AEs of IOP-lowering eye drops by identifying the characteristics that most strongly influence treatment choices.

Italian glaucoma virtual clinics: Developing a consensus for remote patient management.

This Delphi panel provides guidance for implementing glaucoma virtual clinics in Italy, establishing guidelines on patient selection, required assessments and staffing needs.

Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: A Systematic Review and Meta-Analysis.

Intraoperative sub-Tenon MMC injection is noninferior to intraoperative MMC-soaked sponges in trabeculectomy surgery in terms of surgical failure and IOP control, with a reduced number of medications, improved bleb morphology, and similar safety profile.

Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma: A Systematic Review of Diagnostic Accuracy Studies.

With the use of OCT, RNFL parameters are still preferable to macular parameters for diagnosing manifest glaucoma, but the differences are small.