Wang Xiaofei

Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements.

Following eye movements, our models predicted high optic nerve sheath traction forces of the same order of magnitude as extraocular muscle forces.

In Vivo Three-Dimensional Lamina Cribrosa Strains in Healthy, Ocular Hypertensive, and Glaucoma Eyes Following Acute Intraocular Pressure Elevation.

We demonstrate measurable LC strains in vivo in humans as a response to acute IOP elevation. In this population, our data suggest that OHT LCs experience lower IOP-induced strains than healthy LCs.

DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images.

DeshadowGAN significantly corrected blood vessel shadows in OCT images of the ONH.

In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans.

We have developed a methodology to assess the biomechanical properties of human ONH tissues in vivo and provide preliminary comparisons in healthy and OHT subjects. Our proposed methodology may be of interest for glaucoma management.

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects.

In this sample, subjects with glaucoma exhibited tauter optic nerves and more protruding eye globes compared with normal eyes. This may impact optic nerve head deformations in anatomically predisposed patients.

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head.

Our study revealed that eyes with HMG experienced significantly greater strains under IOP compared to eyes with HM. Furthermore, eyes with PM + S had the highest strains on the ONH of all groups.

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head.

In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, whereas the LC became stiffer.

Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Patients with Normal- and High-Tension Glaucoma.

We found significant negative associations between IOP-induced ONH strains and retinal sensitivity in a relatively large glaucoma cohort.

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length.

This study demonstrates that gaze-induced ONH deformations increase with axial elongation.

An automated optical coherence tomography to finite element analysis pipeline reveals key morphological determinants of optic nerve head biomechanics in glaucoma.

This study presents a scalable, image-based biomechanical framework enables high-throughput, patient-specific assessment and offers new opportunities to identify morphological biomarkers for glaucoma risk stratification and disease monitoring.

Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations.

Straighter optic nerves and decreased ILPP distance could cause RNFL thinning, possibly due to greater traction forces.

High Myopia-Induced Optic Nerve Head Deformation and Glaucoma Progression: A Three-Year Follow-Up Study.

HM-induced ONH deformation, particularly nasal tilting and reduced NCMCA, accelerates temporal glaucomatous damage. NCMCA serves as a critical biomarker for progression risk, supporting individualized management in glaucoma with HM.

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.

Our findings indicate that the macula in HMG, PM, and PM+S eyes showed greater curvature changes under IOP elevation compared to HM and emmetropic eyes.

Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study.

Our study demonstrated the associations of static and dynamic iris parameters in healthy Chinese individuals. The findings provided a possible explanation for the higher prevalence of primary angle closure disease in elderly and female populations.

Investigating the determinants of iridolenticular contact area: a novel parameter for angle closure.

ILCA is a significant predictor of angle closure independent of other biometric factors and may reflect unique anatomical information associated with pupillary block. ILCA represents a novel biometric risk factor in eyes with angle closure.

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.

Our models predicted high ONH strains during eye movements, which were aggravated with stiffer optic nerve sheaths.