Wang Ya Xing

Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features.

In highly myopic eyes (cut-off for high myopia at approximately -8 diopters or an axial length of 26.

Myopia: Histology, clinical features, and potential implications for the etiology of axial elongation.

Myopic axial elongation is associated with various non-pathological changes.

Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects.

Beyond 26.0 mm of axial length, horizontal and vertical BMO diameter increased by 0.21 mm (95%

Physical activity and eye diseases. The Beijing Eye Study.

Higher physical activity and less sedentary lifestyle were associated with a lower prevalence of diabetic retinopathy, while the occurrence of other major ocular diseases such as any type of cataract and of glaucoma, retinal vein…

Intraocular pressure elevation and choroidal thinning.

Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test.

Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.

In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness.

The Proportion of Individuals Likely to Benefit from Customized Optic Nerve Head Structure-Function Mapping.

Anatomically customized mapping shifts the map markedly in approximately 12% of the general population in the nasal step region, where visual field locations can map to the opposite pole of the ONH than conventionally considered.

Retinal Nerve Fiber Layer Thickness and Rim Area Profiles in Asians: Pooled Analysis from the Asian Eye Epidemiology Consortium.

In this large pooled analysis of Asian population studies, Indian and Japanese eyes were observed to have thinner RNFL profiles. These findings suggest the need for an ethnic-specific normative database to improve glaucoma detection.

OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.

Our data suggest that pNC-SB is increased and pNC-CT is decreased in highly myopic eyes and that these phenomena are greatest in the inferior sectors.

Positive and Negative Associations of Myopia with Ocular Diseases in Population-Based Studies.

Myopia is associated with a lower prevalence of DR, AMD, and ACG and a lower incidence of DR and AMD, whereas high myopia more than moderate myopia is associated with a higher prevalence and incidence of OAG.

Peripapillary choroidal vascular layers: the Beijing Eye Study.

Small-to-medium vessel layer (SMVL) and LVL, thickest superiorly and thinnest inferiorly, increased with younger age and higher cognitive function after adjusting for axial length and prevalence of angle-closure glaucoma.

Prevalence, Features, and Risk Factors of Macular Retinoschisis in High Myopic Population: The Beijing Eye Study 2011.

The prevalence of MRS was 27.9% among the elderly highly myopic population.

Prevalence and Associations of Peripheral Arterial Disease in China: The Beijing Eye Study.

The PAD prevalence (3.0%, 95% CI 2.0%, 4.0%) was relatively low in this cohort from rural and urban Beijing, with older age, lower educational level, lower quality of life, higher glucose serum concentration, lower estimated…

Associations of fundus tessellation, myopic diffuse chorioretinal atrophy and choroidal thickness with visual acuity in myopia.

MMD stage 1 (fundus tessellation) is associated with decreased BCVA and may be considered pathological.

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length.

This study demonstrates that gaze-induced ONH deformations increase with axial elongation.

Global Glaucoma Prevalence: Burden and Projection to 2060.

There is a significant, previously underestimated, increase in OAG burden globally, driven by the rising prevalence of myopia.

Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.

Higher IOP and longer AXL are associated with distinct structural changes of the ONH in highly myopic eyes, particularly involving the lamina cribrosa.

Glaucomatous, Glaucoma-Like, and Non-Glaucomatous Optic Neuropathy in High Myopia: The Two-Continent Study.

Highly myopic eyes had considerable prevalences of NGON and GLON/GON, usually higher than 20% and 10%, respectively.

Ocular and General Determinants of Intraocular Pressure: The Two-Continent Eye Study.

Among numerous ocular and systemic factors influencing IOP readings (with a relative low correlation coefficient), corneal curvature radius was one of the main ocular determinants.

Retinal Thickness and Axial Length.

Myopic axial globe elongation was associated with retinal thinning in the equatorial and pre-equatorial region, while foveal retinal thickness was mostly unaffected by axial length.

Reply: To PMID 25556115.

Incident retinal vein occlusions and estimated cerebrospinal fluid pressure. The Beijing Eye Study.

A higher estimated CSFP was associated with a higher incidence of RVOs originating at the optic nerve head (i.e.

Acute Peripapillary Retinal Pigment Epithelium Changes Associated with Acute Intraocular Pressure Elevation.

Eyes with an acute rise in IOP (>15 mmHg) showed a folding and centrifugal sliding of the peripapillary RPE and, after IOP reduction, centripetal RPE movement.

Fundus Tessellation: Prevalence and Associated Factors: The Beijing Eye Study 2011.

Fundus tessellation is a surrogate for choroidal thinness and may be a clinical sign for a leptochoroid.

Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011.

The 10-year incidence of localized RNFLDs in adult Chinese is 4.7% ± 0.2%.

Peripapillary Choroidal Thickness in Adult Chinese: The Beijing Eye Study.

Peripapillary choroidal thickness measurements were available for 3060 (88.2%) study participants with a mean age of 64.4 ± 9.6 years (range, 50-93 years).

Optic nerve head changes after short-term intraocular pressure elevation in acute primary angle-closure suspects.

Angle-closure suspect eyes showed a widening and deepening of the optic cup, decrease in neuroretinal rim width, and thinning of the LC after a darkness-induced IOP increase of >15 mmHg.

Reversibility of retinal pigment epithelium detachment parallel to acute intraocular pressure rise.

Slight detachments of the RPE may depend on acute IOP changes.

Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011.

In OAG, but not in ACG, calculated TLCPD versus IOP showed a better association with glaucoma presence and amount of glaucomatous optic neuropathy.