Wollstein Gadi

Cholinergic nervous system and glaucoma: From basic science to clinical applications.

Since glaucoma is a form of neurodegeneration involving retinal ganglion cells, citicoline may help ameliorate glaucomatous damages in multiple facets.

Can Macula and Optic Nerve Head Parameters Detect Glaucoma Progression in Eyes with Advanced Circumpapillary Retinal Nerve Fiber Layer Damage?

Macula GCIPL and ONH parameters may be useful in tracking progression in patients with advanced glaucoma.

Adaptive optics optical coherence tomography in glaucoma.

It is now possible to visualize discrete structures within the posterior eye, such as photoreceptors, retinal nerve fiber layer bundles, the lamina cribrosa, and other structures relevant to glaucoma.

Estimating Global Visual Field Indices in Glaucoma by Combining Macula and Optic Disc OCT Scans Using 3-Dimensional Convolutional Neural Networks.

The accuracy of global visual field indices estimate is improved by integrating information from MAC and ONH in advanced glaucoma, suggesting that structural changes of the 2 regions have different time courses in the disease…

In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography.

IPL sublayer analysis revealed that the middle sublayer could be responsible for the majority of IPL thinning in glaucoma. Vis-OCT quantified IPL sublayers with good repeatability in both glaucoma and healthy subjects.

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.

A higher dose of POAG risk alleles was associated with an earlier age at glaucoma diagnosis.

The Future of Imaging in Detecting Glaucoma Progression.

Furthermore, extracting functional information from scans such as blood flow rate and oxygen consumption provides new perspectives on the disease and its progression.

Artificial Intelligence for Optical Coherence Tomography in Glaucoma.

DL models are reshaping glaucoma management by enhancing OCT's diagnostic capabilities.

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.

Collectively, testosterone metabolism pathway SNPs were consistently associated with the high-tension subtype of POAG in two datasets.

Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models.

Chronic IOP elevation was accompanied by decreased fractional anisotropy and increased radial diffusivity along the optic nerve or optic tract, suggestive of disrupted microstructural integrity in both inducible and genetic glaucoma animal models.

Forecasting Retinal Nerve Fiber Layer Thickness from Multimodal Temporal Data Incorporating OCT Volumes.

The performance of the proposed forecasting model for cpRNFL is consistent across glaucoma suspect and glaucoma patients, which implies the robustness of the developed model against the disease state.

Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility.

Thick prelaminar tissue was associated with impaired visualization of the LC. Healthy subjects generally had thicker prelaminar tissue, which potentially could create a selection bias against healthy eyes when comparing LC structures.

Clinical Prediction Performance of Glaucoma Progression Using a 2-Dimensional Continuous-Time Hidden Markov Model with Structural and Functional Measurements.

The 2D CT HMM demonstrated promising prediction performance in detecting glaucoma change performance in a simulated clinical setting using an independent cohort.

Microstructural Deformations Within the Depth of the Lamina Cribrosa in Response to Acute In Vivo Intraocular Pressure Modulation.

The LC deforms unevenly throughout its depth in response to IOP modulation at fixed ICP.

Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.

Increasing IOP acutely caused nonlinear LC deformations with an overall smaller effect postmortem than premortem.

Lamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning.

Global and sectoral microstructural differences were detected when comparing thin and normal RNFL-T eyes. Whether these LC differences are the cause of RNFL damage or the result of remodeling of the LC requires further investigation.

Peripapillary Atrophy Area as an Indicator of Glaucomatous Structural and Functional Progression.

Longitudinal change in PPA area is an indicator of glaucomatous structural and functional progression but PPA area at baseline cannot predict future progression.

Can Glaucoma Suspect Data Help to Improve the Performance of Glaucoma Diagnosis?

Exploiting glaucoma suspect eyes in a semi-supervised learning method coupled with resampling can improve glaucoma diagnosis performance by mitigating imbalanced learning issues.

Contributions of Brain Microstructures and Metabolism to Visual Field Loss Patterns in Glaucoma Using Archetypal and Information Gain Analyses.

Our findings highlight the importance of non-invasive neuroimaging biomarkers and analytical modeling for unveiling glaucomatous neurodegeneration and how they reflect complementary VF loss patterns.

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

RNFLT-PN reduces normative variability, especially in the ST and IT regions.

Optic Nerve Imaging-From Disc Photos to OCT.

In this review, we summarize the major advances in ocular imaging technologies and their contributions to the understanding, diagnosis, and monitoring of glaucoma over the past 2 centuries.

Disparities in Visual Field Testing Frequency Among Subjects With Glaucoma.

Black and Asian subjects with glaucoma receive fewer VFT per visit compared to White subjects even when considering socioeconomic disadvantage and disease severity.

Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation.

Baseline pore tortuosity and the response to acute pressure increase vary substantially across eyes.

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Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses.

We present an effective approach for assessing the contributions of mitochondrial genetic variation to open-angle glaucoma.

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.

Our integrative study is the first to associate rs76481776 with POAG via elevated miR-182 expression.

Clinical Utility of Optical Coherence Tomography in Glaucoma.

This article reviews the history of OCT imaging with a specific focus on glaucoma.

Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices.

The interdevice differences in CDR and cup volume are primarily caused by the devices' proprietary ONH analysis algorithms.

Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk.

These findings results demonstrate the importance of considering the anatomical location of CRVT in the assessment of the LC, as there is a relationship between the distance from the CRVT and the LC microstructure, which…

Glaucoma Structural and Functional Progression in American and Korean Cohorts.

Ethnicity, baseline disease severity, disease subtype, and clinical diagnosis should be considered when comparing glaucoma progression studies.

Agreement among graders on Heidelberg retina tomograph (HRT) topographic change analysis (TCA) glaucoma progression interpretation.

A simple set of predefined common criteria improves agreement between graders in assessing TCA progression.