Wu Jihong

Decreased d-Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model.

Increased d-Serine and SR expressions in the retina of the COH model were detected.

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension.

Elevated SARM1 expression was observed in the optic nerves in both the COH and I/R injury models.

Immediate Impact of Acute Elevation of Intraocular Pressure on Cortical Visual Motion Processing.

In contrast to human chronic glaucoma that may cause greater dysfunction in large-cell magnocellular than in small-cell parvocellular visual pathways, our direct measurement of cortical processing networks implies that the small X-cell pathway shows greater…

Plasma Proteomic Dynamics Preceding Glaucoma Reveal a 15-Year Pre-Diagnostic Window: Causal Insights and Predictive Utility in 45,850 Participants.

This study reveals a 15-year window of detectable plasma proteomic dysregulation preceding glaucoma diagnosis.

eNOS Activity in CAV1 Knockout Mouse Eyes.

Although CAV1 KO mice had elevated IOP and decreased outflow facility, CAV1 deficiency (and possibly the loss of CAV2) resulted in increased eNOS activity.

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice.

NOS3 KO mice have elevated IOP, which is likely the result of reduced pressure-dependent drainage.