Xia Xiaobo

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway.

In response to ER stress inducers, TMSCs activated a lower level of UPR and lasted shorter than TM cells.

Ripasudil in a Model of Pigmentary Glaucoma.

In vitro, K-115 reduced TM stress fibers, restored phagocytosis, and restored migration of TM cells. Ex vivo, K-115 normalized intraocular pressure.

Targeting Bcl3/NF-κB p50 Pathway for Neuroinflammation Attenuation and RGCs Protection in Retinal Ischemia/Reperfusion Injury.

This study provides insights into RSV's molecular mechanisms and identifies new therapeutic targets for glaucoma.