Yamamoto Tetsuya

Evaluation of a New Rebound Self-tonometer, Icare HOME: Comparison With Goldmann Applanation Tonometer.

The Icare HOME tonometer is feasible for use in self-monitoring of IOP. Icare HOME tonometry measurements tend to overestimate IOP relative to GAT measurements.

Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C.

Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

Reporting Harm in Glaucoma Surgical Trials: Systematic Review and a Consensus-Derived New Classification System.

Glaucoma surgical randomized controlled trials report frequency of complications, but their severity is rarely reported.

Ripasudil-Brimonidine Fixed-Dose Combination vs Ripasudil or Brimonidine: Two Phase 3 Randomized Clinical Trials.

The IOP-lowering effect of RBFC was superior to that of ripasudil or brimonidine.

Long-term clinical course of normotensive preperimetric glaucoma.

Our findings confirmed that the mean IOP, but not the IOP fluctuation, is strongly associated with the development of a VFD in cases of PPG.

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma.

Timolol should be considered a potential therapeutic agent specific to OPTNE50K-NTG because it can reduce the OPTNE50K aggregation in E50K-iPSCs-RGCs by enhancing autophagic flux and neuroprotective effects.

Randomized, Controlled, Phase 3 Trials of Carteolol/Latanoprost Fixed Combination in Primary Open-Angle Glaucoma or Ocular Hypertension.

OPC-1085EL is superior to latanoprost or carteolol alone in terms of lowering IOP, and was well tolerated.

Comparison of Changes in Macular Ganglion Cell-Inner Plexiform Layer Thickness Between Medically and Surgically Treated Eyes With Advanced Glaucoma.

The structure of the mGCIPL was better preserved in STE than in MTE, even when the IOPs during follow-up were similar.

Localization in Glaucomatous Visual Field Loss Vulnerable to Posture-Induced Intraocular Pressure Changes in Open-Angle Glaucoma.

Posture-induced IOP variations have been shown to be associated with glaucomatous superior paracentral visual field defects.

Effects of ambient atmospheric pressure on intraocular pressure measured using a Goldman applanation tonometer in normal eyes under ordinary conditions.

AP was found to have a significantly positive correlation with GAT-IOP in normal healthy eyes under ordinary conditions, though the actual impact of AP on IOP in normal individuals under ordinary conditions would be minimal.

Frequencies of 4 Distinct Patterns of Glaucomatous Disc Appearance and Their Clinical Associations in Japanese Population-based Studies.

The FG type occurs most frequently in Japanese POAG followed by the GE type.

Blindness and prognostic factors after trabeculectomy with mitomycin C in patients with open-angle glaucoma with long-term follow-up.

One-eighth and one-sixth of the eyes became blind at 10 and 20 years post-trabeculectomy using MMC.

Reply.

Long-term intraocular pressure-lowering efficacy and safety of ripasudil-brimonidine fixed-dose combination for glaucoma and ocular hypertension: a multicentre, open-label, phase 3 study.

These data demonstrated the long-term efficacy and safety of RBFC, both alone and in combination with other anti-glaucoma agents. RBFC may offer a new treatment option for the long-term management of glaucoma and OHT.

Development of Glaucomatous Visual Field Defects in Preperimetric Glaucoma Patients Within 3 Years of Diagnosis.

Significant structural changes were observed in the mGCIPL and cpRNFL at PPG diagnosis, before the development of a VFDs. Close monitoring of intraocular pressure is essential for the appropriate management of PPG.

Fluctuation of Bacteria on Bleb Surface After Trabeculectomy With Adjunctive Mitomycin C.

It is not rare to detect the bacterial organisms on the bleb surface in glaucomatous eyes that had undergone trabeculectomy. The prevalence varied with the season and was highest in the autumn.

One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.

Fifty-two week administration of 0.4% ripasudil revealed IOP-lowering effects and an acceptable safety profile when administered as monotherapy or as additive therapy, in patients with open-angle glaucoma or OHT.

Seasonal Variation in the Incidence of Late-onset Bleb-related Infection After Filtering Surgery in Japan: The Japan Glaucoma Society Survey of Bleb-related Infection Report 3.

The incidence of late-onset bleb-related infection showed significant seasonal variation and sex differences.

Additive Intraocular Pressure-Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials.

These clinical trials found additive IOP-lowering effects of ripasudil from placebo at trough and peak levels in combination with timolol and at peak level in combination with latanoprost.

Progression to Legal Blindness in Patients With Normal Tension Glaucoma: Hospital-Based Study.

The probability of blindness in eyes with NTG is much lower than previously reported in patients with high-tension glaucoma.

Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study.

Ripasudil is a promising new topical medication to lower IOP for at least 7 hr after instillations in patients with POAG or OHT.