Ye Wen

Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.

Losartan attenuates scar formation of filtering bleb after trabeculectomy likely via decreasing proliferation, migration, transdifferentiation, and extracellular matrix deposition of Tenon's fibroblasts.

Angiotensin II as a morphogenic cytokine stimulating fibrogenesis of human tenon's capsule fibroblasts.

Our results show that trabeculectomy alter the levels of Ang II and its receptors in Tenon's capsule fibroblasts, and that Ang II increase HTFs proliferation, migration, and phenotype transition, suggesting that Ang II may play…