Nazlee Zebardast

Racial and Socioeconomic Differences in Eye Care Utilization among Medicare Beneficiaries with Glaucoma.

Disparities were found in eye care utilization among Black and Hispanic patients with glaucoma. These differences persisted among Blacks after stratification by SES, suggesting that systemic racism may be an independent driver in this population.

Trends and Usage Patterns of Minimally Invasive Glaucoma Surgery in the United States: IRIS® Registry Analysis 2013-2018.

A significant increase in MIGS use occurred over the recent 6-year period, despite limited evidence of their long-term safety or effectiveness, highlighting the need for trials comparing safety and outcomes of novel MIGS versus traditional…

Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes.

In a South Indian population with PACS or PAC/PACG, LPI results in significant anterior chamber angle widening seen on both ASOCT and gonioscopy, although some degree of persistent iridotrabecular contact was present in approximately half…

Race and Ethnicity Differences in Disease Severity and Visual Field Progression Among Glaucoma Patients.

Black, Asian and Hispanic patients had greater baseline severity vs.

Comparison of New Visual Disturbances after Superior versus Nasal/Temporal Laser Peripheral Iridotomy: A Prospective Randomized Trial.

Laser peripheral iridotomy likely is safe with respect to visual dysphotopsias regardless of location, LPI size, and amount of laser energy used.

Effectiveness of Microinvasive Glaucoma Surgery in the United States: Intelligent Research in Sight Registry Analysis 2013-2019.

In current United States clinical practice, MIGS has substantially lower reoperation rates when performed with phacoemulsification, especially for ECP and goniotomy or canaloplasty.

Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.

Results suggest that PRS identified a group of individuals at substantially higher risk for POAG.

Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.

Higher PRS was associated with increased risk for POAG in patients with ocular hypertension. The inclusion of a PRS improved the prediction of POAG onset.

Racial Disparities in Glaucoma Vision Outcomes and Eye Care Utilization: An IRIS Registry Analysis.

We found that significant disparities in US eye care exist with Black, Hispanic, and Native American patients having worse vision outcomes and less disease monitoring.

Effectiveness of Trabeculectomy and Tube Shunt with versus without Concurrent Phacoemulsification: Intelligent Research in Sight Registry Longitudinal Analysis.

Reoperation rates within the first 3 years after trabeculectomy and GDD with and without phacoemulsification were low.

Resolution of Visual Dysphotopsias after Laser Iridotomy: Six-Month Follow-up.

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.

One in 4 individuals with the MYOC p.Gln368Ter mutation demonstrated evidence of glaucoma, a substantially higher penetrance than previously estimated, with 69% of cases undetected.

Effect of a Schlemm's Canal Microstent on Early Postoperative Intraocular Pressure after Cataract Surgery: An Analysis of the HORIZON Randomized Controlled Trial.

The addition of an HMS at the time of cataract surgery lowered the risk of markedly elevated IOP in the early postoperative period in patients with glaucoma.

Implementation of an Online Glaucoma-Specific Quality of Life Computerized Adaptive Test System in a US Glaucoma Hospital.

Pilot implementation of six GlauCAT QOL tests in glaucoma outpatient clinics was feasible and acceptable. Integration of GlauCAT with electronic medical records (EMRs) and evaluation of long-term implementation outcomes are needed.

Glaucoma and Machine Learning: A Call for Increased Diversity in Data.

Treatment Patterns of Childhood Glaucoma in the United States: Analysis of IRISRegistry (Intelligent Research in Sight).

We found that 1 in 6 childhood glaucoma eyes underwent glaucoma-related procedures, and nearly all received antiglaucoma medications.

Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record-Linked Biobanks.

A POAG PRS performed similarly using either manual review or ICD codes in 2 electronic health record-linked biobanks; manual assessment of glaucoma status might not be necessary for some PRS studies.

Machine Learning-Derived Baseline Visual Field Patterns Predict Future Glaucoma Onset in the Ocular Hypertension Treatment Study.

Baseline VFs, prior to detectable glaucomatous damage, contain occult patterns representing early changes that may increase the risk of POAG onset and VF progression in patients with ocular hypertension.

Normative Percentiles of Retinal Nerve Fiber Layer Thickness and Glaucomatous Visual Field Loss.

Our results challenge the assumption that normative percentiles from OCT machines improve prediction of glaucomatous visual field loss.

Relationship between Claims-Based Frailty Index and Eye Care Utilization among Medicare Beneficiaries with Glaucoma.

Compared with nonfrail/prefrail Medicare beneficiaries with glaucoma, beneficiaries with moderate-to-severe frailty had lower rates of eye care utilization in the outpatient setting and higher rates of utilization in acute care settings.

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts.

Incorporating a PRS into a POAG predictive model improves identification concordance from 0.75 up to 0.82, supporting its potential for guiding more cost-effective screening strategies.

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.

These findings support a causal effect of elevated blood pressure on retinal ganglion cell degeneration that does not require intermediary changes in IOP.

Effectiveness of Angle-Based Minimally Invasive Glaucoma Surgery after Laser Trabeculoplasty: An Analysis of the IRIS® Registry (Intelligent Research in Sight).

Prior LTP may be associated with a higher chance of subsequent glaucoma surgery following ab-MIGS, either with or without concurrent phacoemulsification.

The Heritability of Primary Angle Closure Anatomic Traits and Predictors of Angle Closure in South Indian Siblings.

Iris, anterior chamber, and lens parameters may be heritable whereas angle parameters were not.

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

These findings support considering use of a POAG PRS threshold to identify individuals at low risk of disease onset, with those below the PRS threshold more likely to have lower conversion rates over 20 years.

Population-Based Utility of van Herick Grading for Angle-Closure Detection.

Transformer-Based Deep Learning Prediction of 10-Degree Humphrey Visual Field Tests From 24-Degree Data.

The predicted 10-2 VF has the potential to improve glaucoma diagnosis.

The Effectiveness of Intracameral Moxifloxacin Endophthalmitis Prophylaxis for Trabeculectomy.

Intracameral moxifloxacin prophylaxis was associated with a nearly 4-fold lower rate of early postoperative endophthalmitis in patients undergoing trabeculectomy or combined trabeculectomy plus cataract extraction.

Corneal Endothelium Changes 6 Months after Laser Peripheral Iridotomy: Prospective Study.

Surgical Outcomes and Risk Factors for Failure in Childhood Glaucoma: Analysis of the IRIS® Registry (Intelligent Research in Sight).

Surgical failure was common in approximately half of all cases.

Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

With increasing age, an mtGPRS was a better predictor of higher IOP and glaucoma prevalence. It is useful to consider chronological age with genetic information in designing glaucoma screening strategies.

Predictors of Short-Term Intraocular Pressure Change after Laser Peripheral Iridotomy: A Prospective Randomized Study.

Neither LPI location nor degree of gonioscopic angle opening was associated with statistically significant change in IOP after LPI.

Geographic Distribution of Access to Glaucoma Surgery: An IRIS® Registry (Intelligent Research in Sight) Analysis.

Patients are more likely to receive most types of glaucoma surgeries in urban practice locations.

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling.

CDR is subject to ceiling effects for glaucoma-related outcomes and poor at discriminating early glaucomatous damage. CDR values should be interpreted with care, particularly in screening settings.

ChatGPT-Assisted Glaucoma Diagnosis: A Health-Equitable Multi-Ancestry Analysis Using Visual Field and Optical Coherence Tomography Data.

ChatGPT o1 Pro diagnosed glaucoma similarly to specialists using only VF and OCT data. The model performance was similar across ancestral groups and genetic predispositions to glaucoma.

Corneal Endothelial Keratoplasty Following Glaucoma Treatment: An American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Analysis.

This large study highlights the substantially elevated risk of endothelial keratoplasty following traditional glaucoma surgeries such as tube/shunt implantation and trabeculectomy as well as the modestly increased risk associated with chronic topical glaucoma therapy.

Comparison of Glaucoma Surgery Incidence and Outcomes in Pseudoexfoliation and Primary Open-Angle Glaucoma: IRIS® Registry Analysis.

Patients with PXG were nearly twice as likely to undergo glaucoma surgery than those with POAG, even when the baseline characteristics were balanced, reflecting the more aggressive nature of PXG.

Causes and Treatments of Malignant Glaucoma in the United States: Analysis of IRIS® Registry.

More than half of the eyes with MG had a pre-existing glaucoma diagnosis.

Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.

Trunk-branch VF classifiers were superior to trunk-only characterizations for predicting functional progression and glaucoma PRS.

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.

Our results demonstrate that while PRSs predict glaucoma risk at the cohort level, their instability at the individual level limits stand-alone clinical application.

Generative Artificial Intelligence for Retinal Image Translation to Improve Glaucoma Screening With Deep Learning.

GANs effectively translate SLO images into synthetic CF photographs, addressing domain shifts and increasing dataset sizes to enhance glaucoma detection.

Factors Associated With Gonioscopy Coding Before Glaucoma Procedures in the IRISRegistry.

Preoperative gonioscopy use and/or coding is lower than expected, given current guidelines. Among glaucoma procedures, ab interno MIGS were associated with lower preoperative gonioscopy utilization.

The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma.

Lower SE values are associated with worse paracentral VF loss. Worse myopia is associated with functional progression, even when excluding patients with high myopia.

Genetic Risk for Open-Angle Glaucoma Subtypes Is Associated with Specific Visual Field Defect Classes.

Higher POAG PRSs and NTG PRSs were associated with paracentral VF loss, whereas higher HTG GRS was linked to total VF loss, but not paracentral defects.

Ophthalmological Examination and Imaging Features that Better Predict Risk of Angle Closure in Siblings.

Structural features of eyes with angle closure may assist in stratifying the risk of angle closure in patients' siblings.

Impact of Demographics on Regional Visual Field Loss and Deterioration in Glaucoma.

Blacks and non-English speakers have more severe VF loss, with superior hemifield being more affected and faster VF worsening.

Sodium-Glucose Cotransporter 2 Inhibitors for the Primary Prevention of Glaucoma in Patients With Type 2 Diabetes: A Target Trial Emulation.

Patients on SGLT2i, including canagliflozin, empagliflozin, dapagliflozin, and ertugliflozin, had a significantly lower risk of incident glaucoma compared to those on DPP4i. SGLT2i demonstrated a protective effect for both open-angle glaucoma and angle-closure glaucoma.

Angle Closure Phenotypes in Siblings of Patients at Different Stages of Angle Closure.