Zhang Ye

Progression of Primary Angle Closure Suspect to Primary Angle Closure and Associated Risk Factors: The Handan Eye Study.

We report the progression from baseline PACS to PAC/PACG after five years. And baseline mean angle width was determined to be independent predictive risk factor for the progression of angle closure.

Development of angle closure and associated risk factors: The Handan eye study.

This study reports the development from baseline open angle to angle closure after a 5-year follow-up.

Anterior Segment Characteristics and Risk Factors for Primary Angle Closure Disease With Long Axial Lengths: The Handan Eye Study.

PACD with long AL was uncommon. A thicker peripheral iris, larger lens vault, and smaller ACW contributed to angle closure in these patients.

Establishment and Comparison of Algorithms for Detection of Primary Angle Closure Suspect Based on Static and Dynamic Anterior Segment Parameters.

The three algorithms did not meet the requirements for population-based screening of PACS. One possible reason could be the different angle closure mechanisms in enrolled eyes.

Zonulopathy Identified During Cataract Extraction in Patients With Primary Angle Closure Disease.

Zonulopathy is common in PACD, especially in patients with AAC. Shallow anterior chamber depth and thick lens thickness were associated with an increased proportion of zonulopathy.

Association of Hypertriglyceridemia and Incident Glaucoma in a Rural Chinese Population: The Handan Eye Study.

Our study revealed that increased age and high TGs level, one of the baseline metabolic features, were independent risk factors for incident glaucoma.

Five-year incidence of primary glaucoma and related risk factors - The Handan eye study.

We reported the 5-year incidence of primary glaucoma in a rural Chinese population and found that older age, higher IOP, and VCDR ≥ 0.60 at baseline could help in identifying those at highest risk of disease development.

Detection of primary angleclosure suspect with different mechanisms of angle closure using multivariate prediction models.

Prediction models showed the best performance for detection of PACS with PB mechanism for AC and have potential for screening of PACS.

Efficacy of Morning Versus Evening Latanoprost/Timolol Fixed Combination for Open-Angle Glaucoma and Ocular Hypertension: A Randomized Clinical Trial.

Both morning and evening LTFC dosing can effectively reduce 24-hour IOP and IOP fluctuation. Morning dosing is more likely to effectively control diurnal IOP fluctuations.

Variation in Retinal Nerve Fiber Layer and Ganglion Cell Complex Associated With Optic Nerve Head Size in Healthy Eyes.

RNFL but not GCC significantly increased with ONH size in healthy eyes. GCC may be more suitable than RNFL for evaluating early glaucoma in patients with large or small ONH.

Phacoemulsification combined glaucoma surgeries in the treatment of nanophthalmos patients with secondary angle closure glaucoma.

PVP combined with Trab or ECP and PVPTS are effective and safe surgical interventions for patients with NSACG.

Impact of Acute Short-Term Hypobaric Hypoxia on Anterior Chamber Geometry.

After short-term, effortless exposure to hypobaric hypoxia, pupil miosis occurred with widening of the anterior chamber angle and decreased IC.

Surgical Efficacy After Viscogonioplasty in Primary Angle Closure Disease with Different Mechanisms.

Non-PB mechanisms are associated with larger postoperative PAS extent at 1-year follow-up compared to PB mechanisms, emphasizing the importance of comprehensive preoperative angle-closure mechanisms assessment in predicting and potentially minimizing PAS progression for enhanced long-term…

Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.

Our findings underscore the importance of the iris in the pathogenesis of PACG and identified iris-specific, enhancer-modulating variants that may influence disease risk.

Associations of static and dynamic iris parameters in healthy Chinese individuals: the Handan Eye Study.

Our study demonstrated the associations of static and dynamic iris parameters in healthy Chinese individuals. The findings provided a possible explanation for the higher prevalence of primary angle closure disease in elderly and female populations.

Quantitative analysis of dynamic iris changes in primary angle-closure disease with long axial lengths: the Handan Eye Study.

Dynamic and static iris parameters were consistent across patients with PACD with short, medium, or long AL and may contribute to the pathogenesis of angle closure in atypical PACD.

Factors associated with severe corneal endothelial damage following acute primary angle closure in Chinese subjects.

Shortly after the abortion of APAC, 12.28% patients experienced severe endothelial cell damage with ECD less than 1000/mm.

Dynamic Iris Changes as a Risk Factor in Primary Angle Closure Disease.

Significant differences in iris behavior in the dark compared to light in PACS, PACD, and normal eyes add to the evidence that dynamic iris change has a role in the pathogenesis of PAC in a…

Quantitative analysis of iris changes following mydriasis in subjects with different mechanisms of angle closure.

There are significant differences in IA and IA loss per mm of pupil change following physiologic or pharmacologic mydriasis in Chinese subjects with dissimilar dominant mechanisms for AC.