Zhao Yan

Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.

Results suggest that PRS identified a group of individuals at substantially higher risk for POAG.

Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.

Higher PRS was associated with increased risk for POAG in patients with ocular hypertension. The inclusion of a PRS improved the prediction of POAG onset.

Comparison of Perimetric Outcomes from a Tablet Perimeter, Smart Visual Function Analyzer, and Humphrey Field Analyzer.

Although average MD values from the 2 novel devices suggest that they provide similar results to the HFA, point-by-point comparisons highlight notable deviations.

Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record-Linked Biobanks.

A POAG PRS performed similarly using either manual review or ICD codes in 2 electronic health record-linked biobanks; manual assessment of glaucoma status might not be necessary for some PRS studies.

2021 Survey of Keratoplasty Postoperative Steroid Management.

Ninety-two ophthalmologists with a median of 13 years (range of 1-35; mean of 14.5; ±9.05 mean ± SD) of experience as attending clinicians were surveyed.

Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes.

Patients with POAG with higher TXNRD2 and ME3 GRSs showed higher treated IOP and a greater prevalence of paracentral field loss.

Participant Experience Using Novel Perimetry Tests to Monitor Glaucoma Progression.

Users reported a preference for novel VF devices. Overall participant experience using these devices was positive, supporting the feasibility of home monitoring of VFs from an experience perspective.

Effectiveness of Angle-Based Minimally Invasive Glaucoma Surgery after Laser Trabeculoplasty: An Analysis of the IRIS® Registry (Intelligent Research in Sight).

Prior LTP may be associated with a higher chance of subsequent glaucoma surgery following ab-MIGS, either with or without concurrent phacoemulsification.

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

These findings support considering use of a POAG PRS threshold to identify individuals at low risk of disease onset, with those below the PRS threshold more likely to have lower conversion rates over 20 years.

Comparison of structure-function correlation among IMO visual function analyser and Humphrey field analyser.

The IMOvifa test took less time and resulted in slightly less severe defects than HFA. MS in all sectors was moderately to strongly correlated. Function-structure correlations were similar when using either perimeter.

Comparison of Glaucoma Surgery Incidence and Outcomes in Pseudoexfoliation and Primary Open-Angle Glaucoma: IRIS® Registry Analysis.

Patients with PXG were nearly twice as likely to undergo glaucoma surgery than those with POAG, even when the baseline characteristics were balanced, reflecting the more aggressive nature of PXG.

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.

Our results demonstrate that while PRSs predict glaucoma risk at the cohort level, their instability at the individual level limits stand-alone clinical application.

Genetic Risk for Open-Angle Glaucoma Subtypes Is Associated with Specific Visual Field Defect Classes.

Higher POAG PRSs and NTG PRSs were associated with paracentral VF loss, whereas higher HTG GRS was linked to total VF loss, but not paracentral defects.

Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension.

We demonstrated that the functional degeneration of RGCs is subtype-dependent and that the ON and OFF pathways from the retina to the SC were disrupted.