Zhu Xiaofeng

Inhibition of TGF-β2-Induced Trabecular Meshwork Fibrosis by Pirfenidone.

PFD inhibited TGF-β2-induced TM cell fibrosis by rearranging the disordered cytoskeleton and decreasing ECM deposition, thereby enhancing the aqueous outflow from the TM outflow pathway and lowering IOP, which provides a potential new approach to…

Small Extracellular Vesicle Treatment of Trabecular Meshwork Fibrosis: 2D/3D In Vitro and In Vivo Analyses.

hBMMSC sEVs significantly attenuate TGFβ2-induced TM fibrosis via both protein expression and morphological changes. In addition, hBMMSC sEVs have therapeutic potential in alleviating the TGFβ2-induced increase in IOP linked to TM fibrosis.