Zhuo Yehong

Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.

For the first time to our knowledge, these data collectively establish the existence of hallmark AD-like pathologies in the glaucomatous LGN.

Relationships between Frailty and the Risk of Glaucoma in Middle-aged and Older Adults.

Our study revealed an association between frailty and increased glaucoma risk and emphasized the significance of glaucoma screening in frail individuals.

Quantitative Assessment of Fundus Tessellated Density in Highly Myopic Glaucoma Using Deep Learning.

FTD differs in degree and distribution between HMG and HM. A higher macular NT alone or with a lower horizontal parapapillary atrophy/disc ratio may help differentiate HMG.

Detecting Glaucoma in Highly Myopic Eyes From Fundus Photographs Using Deep Convolutional Neural Networks.

Our proposed model demonstrates high efficacy and suggests specific features for distinguishing eyes with HMG, enabling potential clinical value in assisting the intricate diagnosis of this vision-threatening disease.

Predicting the Real-World Future of Glaucoma Patients? Cautions Are Required for Machine Learning.

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG.

This study identified six genes associated with POAG, three of which were novel, offering novel insights into its genetic architecture and systemic regulatory mechanisms.

Multi-Quantitative Assessment of AS-OCTA Complemented AS-OCT for Monitoring Filtering Bleb Function After Trabeculectomy.

The quantitative vascular characteristics detected by AS-OCTA were significant for the bleb monitor. The MVMS-BH-MCS grading system had achieved outstanding accuracy in reflecting the surgical results.

Association Between Outdoor Daylight Exposure Duration and Primary Open-Angle Glaucoma.

Prolonged daylight exposure, particularly during the summer, is associated with an elevated risk of POAG incidence, possibly due to increased IOP. These findings highlight the need for protective strategies against excessive daylight exposure.

Association Between Chronic Pain and Risk of Glaucoma: A Prospective Cohort Study.

This study highlighted the potential cumulative effect of chronic pain across multiple locations on glaucoma risk.

Early Life Body Size Trajectory and the Risk of Primary Open-angle Glaucoma: A Retrospective Cohort Study.

Low adult body size was consistently associated with an increased risk of POAG, emphasizing the importance of avoiding excessive weight loss in early life, which may be critical for reducing the POAG burden.

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia.

Optic disc rotation and tilt may affect the distribution of the pRNFL in HM eyes with or without glaucoma, resulting in abnormal correspondence between structure and function.

Association Between Body Composition and Risk of Primary Open-Angle Glaucoma.

POAG risk differs according to body composition. Maintaining a healthy body composition pattern may mitigate its risk.

Evaluation of an Augmented-Reality Head-Mounted Display Among Patients With Glaucomatous Tunnel Vision.

The AR HMD significantly improved the VF, CS, and visual search performance of patients with glaucomatous tunnel vision, but it did not improve patients' VA and mobility performance.

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony.

Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans.

Age-period-cohort analysis of the global burden of visual impairment according to major causes: an analysis of the Global Burden of Disease Study 2019.

The wide heterogeneity in age-period-cohort effects reflects different stages of societal transition and vision health.