Concept Library

Glaucoma due to 'other eye disorders', mostly following prior ocular procedures, had the highest 2-year failure rates following trabeculectomy (58.5%) and tube shunt surgery (62.2%) among 2483 eyes with secondary glaucoma aged 18 to 40 years.

In eyes with congenital cataracts with posterior polar abnormality (PPA, n = 78), higher neurotrophin-4 (NT-4) (odds ratio [OR] = 1.16; 95% confidence interval [CI], 1.02-1.36; P = 0.028) and platelet-derived growth factor-AA (PDGF-AA) (OR = 1.06; 95% CI, 1.01-1.12; P = 0.027) were associated with postoperative visual axis opacification (VAO) in exploratory Firth logistic regression.

Data suggest that at bottle heights of 41 cm and 81 cm, with indicated settings, venturi settings on the Johnson & Johnson Veritas platform have a lower postocclusion surge magnitude compared with peristaltic settings.

No significant difference was observed in surge duration between venturi and peristaltic phacoemulsification pumps at either 41 cm or 81 cm bottle height.

An experimental study comparing postocclusion surge characteristics of venturi and peristaltic phacoemulsification pump types found a significant difference (P < .01) in postocclusion surge magnitude between venturi and peristaltic pumps at 41 cm and 81 cm bottle heights.

The risk of endophthalmitis was significantly higher for pediatric versus adult patients following cataract surgery (P = 0.014), with an incidence of 0.11% (1 case per 871) in pediatric patients and 0.038% (1 case per 2652) in adult patients.

The incidence of endophthalmitis following standalone MIGS was 0.039% (1 case per 2551) in adults, which was comparable to standard cataract surgery.

Among adults, the highest incidence of endophthalmitis occurred following open globe repair (0.94%, 1 case per 106).

The presence of glaucoma significantly influenced the incidence of immunologic graft rejection following endothelial keratoplasty, with an odds ratio (OR) of 2.28 (95% CI, 1.50-3.46, P < 0.001) in a single-center retrospective case review study of 3546 eyes.

Air pollutants, with the exception of O₃, demonstrated negative interaction terms with temperature in interaction analyses of the temperature-outcome association 180 days after incisional glaucoma surgery, suggesting that the modeled association between lower temperatures and surgical failure risk was stronger at higher pollutant concentrations.

Nonlinear patterns of association between ambient temperature and surgical failure risk after incisional glaucoma surgery appeared more evident in older patients and those with primary open-angle glaucoma.

Under nonlinear specifications, exposure to temperature extremes relative to the mid-range was associated with an increased estimated risk of surgical failure after incisional glaucoma surgery.

Spline-based nonlinear models suggested a U-shaped, asymmetric nonlinear association between ambient temperature and surgical failure risk within prolonged exposure windows (P_nonlinearity < 0.0001) after incisional glaucoma surgery.

Postoperative best-corrected visual acuity (BCVA) improvement was comparable between pars plana vitrectomy (PPV) and anterior vitrectomy (AV) in scleral-fixated intraocular lens (SFIOL) implantation (MD = -0.05, 95% CI: -0.12 to 0.02).

The risks of cystoid macular edema (CME), elevated intraocular pressure (IOP), or vitreous haemorrhage did not differ significantly between pars plana vitrectomy (PPV) and anterior vitrectomy (AV) in scleral-fixated intraocular lens (SFIOL) implantation.

Pars plana vitrectomy (PPV) was associated with a higher risk of intraocular lens (IOL) capture (OR = 3.12, 95% CI: 1.30-7.46, p < 0.01) compared with anterior vitrectomy (AV) in scleral-fixated intraocular lens (SFIOL) implantation.

Pars plana vitrectomy (PPV) was associated with lower odds of retinal detachment (OR = 0.11, 95% CI: 0.02-0.57, p < 0.01) and vitreous prolapse (OR = 0.10, 95% CI: 0.02-0.60, p < 0.01) compared with anterior vitrectomy (AV) in scleral-fixated intraocular lens (SFIOL) implantation.

Eyes with sutureless intrascleral haptic fixated intraocular lenses (SIS-IOLs) showed a high degree of iris mobility when compared with the posterior chamber IOL group (Fleiss Kappa 0.887).

Over time, sutureless intrascleral haptic fixated intraocular lenses (SIS-IOLs) demonstrated a slight posterior displacement of the IOL (0.18 mm shift posteriorly).

Sutureless intrascleral haptic fixated intraocular lenses (SIS-IOLs) were positioned significantly more posteriorly than standard posterior chamber IOLs, with an average aqueous depth of 0.59 mm for SIS-IOLs versus 0.48 mm for posterior chamber IOLs (P < 0.00006).

Trabecular meshwork strip peeling (TP) during hemi-gonioscopy-assisted transluminal trabeculotomy (hemi-GATT) significantly decreases early postoperative intraocular pressure (IOP) spikes and enhances early IOP control, while maintaining surgical success.

Trabecular meshwork strip peeling (TP) during hemi-gonioscopy-assisted transluminal trabeculotomy (hemi-GATT) reduced the risk of intraocular pressure (IOP) spikes (odds ratio [OR], 0.01; 95% CI, 0.01-0.38; P = 0.014).

On multivariable analysis, higher baseline intraocular pressure (IOP) increased the risk of IOP spikes after hemi-gonioscopy-assisted transluminal trabeculotomy (hemi-GATT) (odds ratio [OR], 1.48; 95% CI, 1.08-2.01; P = 0.013).

The frequency of intraocular pressure (IOP) spikes was lower with hemi-gonioscopy-assisted transluminal trabeculotomy (hemi-GATT) with trabecular meshwork strip peeling (TP) compared to standard hemi-GATT without TP (1/14 [7.1%] vs. 10/28 [35.7%]; p = 0.048).

An intraocular pressure (IOP) spike occurred in 11/42 eyes (26.2%) after hemi-gonioscopy-assisted transluminal trabeculotomy (hemi-GATT) at 7.1  4.8 days postoperatively, lasting 6.7  5.1 days, with a mean peak IOP during spikes of 26.2  5.0 mm Hg.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) resulted in endothelial cell density (ECD) of approximately 1500 cells/mm2 at 1 month, remaining stable at 3 months, in Case 2, an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) decreased central corneal thickness (CCT) from 859 m to 535 m in Case 2, an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) restored corneal clarity early after surgery and improved best-corrected visual acuity (BCVA) from 20/400 to 20/20 at 1 month, remaining stable at 3 months, in Case 2, an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) resulted in endothelial cell density (ECD) of approximately 2600 cells/mm2 at 1 month, maintained at 3 months, in Case 1, an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) decreased central corneal thickness (CCT) from 747 m preoperatively to 517 m at 3 months in Case 1, an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

Cultivated human corneal endothelial cell (cHCEC) injection (Vyznova) resolved corneal edema rapidly in Case 1, improving best-corrected visual acuity (BCVA) from 20/2000 to 20/30 at 1 month and 20/25 at 3 months, in an eye with bullous keratopathy and preoperative IOP of ≤4 mm Hg after prior filtering glaucoma procedures.

In unicameral eyes after vitrectomy or glaucoma surgery, simultaneous anterior and posterior chamber gas tamponade with 20% sulfur hexafluoride (SF6) via 23-G PPV resulted in a stable mean intraocular pressure (IOP), changing from 16.9 ± 7.2 mm Hg preoperatively to 19.2 ± 12.5 mm Hg (P = 0.858) at 3 months.

In unicameral eyes after vitrectomy or glaucoma surgery, simultaneous anterior and posterior chamber gas tamponade with 20% sulfur hexafluoride (SF6) via 23-G PPV led to a significant decrease in mean central corneal thickness (CCT) from 723.7 ± 166.2 µm to 533.9 ± 84.8 µm (P = 0.019) at 3 months.

Simultaneous anterior and posterior chamber gas tamponade with 20% sulfur hexafluoride (SF6) via 23-G PPV achieved graft attachment in all 10 Descemet membrane endothelial keratoplasty (DMEK) or rebubbling procedures on day 1 in unicameral eyes after vitrectomy or glaucoma surgery.

Refractive lens exchange (RLE) introduces younger patients to potential complications typically associated with cataract surgery, such as dysphotopsias, uveitis, and retinal detachment.

Implantable collamer lenses (ICLs) are associated with a possible risk of intraocular pressure elevation and cataract formation.

The most common complications from laser-assisted in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and small incision lenticule extraction (SMILE) include flap issues, infectious keratitis, haze, dry eye disease, and corneal ectasia.

Gonioscopy-guided transscleral direct cyclopexy (GTS direct cyclopexy) is a safe, minimally invasive, and repeatable procedure for repairing traumatic cyclodialysis clefts.

Intraocular pressure (IOP) increased from a mean of 6.1 ± 2.8 mmHg preoperatively to 12.63 ± 3.60 mmHg at 6 months postoperatively (p = 0.0007) after gonioscopy-guided transscleral direct cyclopexy (GTS direct cyclopexy) for traumatic cyclodialysis.

Best-corrected visual acuity (BCVA) significantly improved from 1.74 ± 0.98 logMAR preoperatively to 0.90 ± 0.69 logMAR at 6 months postoperatively (p = 0.002) after gonioscopy-guided transscleral direct cyclopexy (GTS direct cyclopexy) for traumatic cyclodialysis.

Gonioscopy-guided transscleral direct cyclopexy (GTS direct cyclopexy) achieved cyclodialysis closure in 19 of 20 eyes (95%) after a single procedure in patients with traumatic cyclodialysis.