Concept Library

In multivariable analysis, nasal Schlemm's canal area (SCA) and nasal scleral spur length (SSL) were independent positive predictors of nasal anterior scleral thickness at 0-3mm from the scleral spur (AST0) (both p < 0.001; model R² = 0.356).

Schlemm's canal area (SCA) and scleral spur length (SSL) were significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).

Anterior scleral thickness at 0-3mm from the scleral spur (AST0) was significantly lower in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups compared with controls in both nasal and temporal quadrants (all p < 0.001).

Cumulative gonioscopy score (sum of gonioscopy grades) was weakly predictive of intraocular pressure (IOP) at all cutoffs (adjusted R2≤0.08) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

Smaller iris area (IA) was associated with ocular hypertension (OHTN) for trabecular iris space area (TISA750) less than 0.05 mm2 (P≤0.03) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

In multivariable models of ocular hypertension (OHTN) (AUC≤0.95), smaller trabecular iris space area (TISA750) was associated with OHTN for TISA750 less than 0.20, 0.10, and 0.05 mm2 (P≤0.03) in 2,360 eyes of 2,360 Chinese American Eye Study participants.

Smaller trabecular iris space area (TISA750) and iris area (IA) were consistently associated (P≤0.04) with higher intraocular pressure (IOP) for TISA750 below 0.20, 0.10, and 0.05 mm2 in 2,360 eyes of 2,360 Chinese American Eye Study participants.

Multivariable stepwise linear regression models and changepoint analysis showed that below a trabecular iris space area (TISA750) measurement of 0.08 mm2, models became increasingly predictive of intraocular pressure (IOP) up to an adjusted R2 of 0.84.

In a prospective-longitudinal population-based study of 826 elderly white subjects, higher intraocular pressure (IOP) was associated with incident open-angle glaucoma (p<0.001).

The all-polymer microfluidic theranostic smart contact lens (AP-TSCL) achieved tonometry-aligned intraocular pressure (IOP) tracking in in vitro (artificial eye model), ex vivo (enucleated bovine eyes), and in vivo (rabbit ocular hypertension) studies.

A novel extravascular motion (EVM) signal detected by optical coherence tomography angiography (OCTA) represents pulsatile tissue displacement caused by the cardiac cycle, is most commonly adjacent to arteries, more prominent in experimental glaucoma (EG) eyes, and strongly influenced by intraocular pressure (IOP), suggesting altered biomechanical properties of the vasculature and/or paravascular retinal parenchyma.

Extravascular motion (EVM) lines, detected by optical coherence tomography angiography (OCTA), were more numerous at higher intraocular pressure (IOP) and in experimental glaucoma (EG) compared to fellow control eyes (P < 0.0001) in rhesus macaques, even after accounting for IOP at the time of scan acquisition (P < 0.01).

Subjects with a higher intraocular pressure (IOP) and thinner central corneal thickness (CCT) showed greater posterior remodeling of the lamina cribrosa (LC) as glaucoma functionally progressed in POAG patients, indicating that these factors are mechanistically relevant to glaucomatous remodeling.

Functionally progressive glaucoma in POAG patients was associated with less change in anterior lamina cribrosa surface depth (ALCSD) and lamina cribrosa curvature index (LCCI) in older subjects and subjects with thicker central corneal thickness (CCT) and lower mean intraocular pressure (IOP) over the follow-up period.

The same degree of anterior lamina cribrosa surface depth (ALCSD) change was associated with faster visual field progression in POAG patients who were younger (P = 0.038), had higher central corneal thickness (CCT) (P < 0.001), or had higher mean intraocular pressure (IOP) (P = 0.030).

The association between intraocular pressure (IOP) and myopia or axial length (AL) became progressively less positive with increasing age in school-age Chinese children.

In school-age Chinese children aged <10 years, a higher baseline intraocular pressure (IOP) correlated with greater myopic refraction (P = 0.02), but this correlation was not significant in older children (P = 0.19).

There was no significant within-subject change in intraocular pressure (IOP) between baseline and 3-year follow-up (P = 1.00) in school-age Chinese children.

Central-corneal thickness (CCT) and sex most significantly influenced intraocular pressure (IOP) in school-age Chinese children, based on a retrospective cohort study of 12,914 participants (25,823 eyes).

In school-age Chinese children, a higher intraocular pressure (IOP) was significantly associated with thicker central-corneal thickness (CCT, standardised-regression coefficient (SRC): 0.28, P < 0.001), female gender (SRC: 0.18, P < 0.001), longer axial length (AL, SRC: 0.08, P < 0.001), deeper anterior chamber (SRC: 0.06, P < 0.001), higher mean-keratometry reading (SRC: 0.04, P < 0.001), higher spherical equivalent (SRC: 0.04, P = 0.002), higher body-mass-index (SRC: 0.03, P < 0.001), higher age (SRC: 0.02, P = 0.02), and smaller White-to-White (SRC: -0.03, P < 0.001).

The average intraocular pressure (IOP) in school-age Chinese children from a large-scale longitudinal study was 14.94 ± 3.13 mmHg for those ≤6 years, 15.31 ± 2.93 mmHg for 7-9 years, 15.57 ± 2.85 mmHg for 10-12 years, and 16.12 ± 2.85 mmHg for those >12 years (P < 0.001).

In a retrospective cohort study of 992 eyes that underwent trabeculectomy with mitomycin-C (MMC), 284 eyes (28.6%) met the criteria for numerical hypotony, defined as intraocular pressure (IOP) ≤5 mmHg in 2 or more consecutive visits, at least one of them ≥ 3 weeks after surgery.

iCare measurements of intraocular pressure (IOP) showed significant elevation at 1 month postoperatively (P = 0.005) and Tonopen measurements showed significant elevation at 1 month and 3 months (both P < 0.001) in eyes with keratoconus after corneal collagen cross-linking (CXL), with no elevation observed beyond 3 months with any tonometry method.

Tonopen measurements of intraocular pressure (IOP) were consistently higher than iCare measurements (all P < 0.001) in patients with keratoconus undergoing corneal collagen cross-linking (CXL).

No significant intraocular pressure change was observed in untreated fellow eyes at any postoperative time point following corneal collagen cross-linking (CXL) in patients with keratoconus.

Intraocular pressure (IOP) significantly increased by 2.2 mmHg (P = 0.001) at 1 month and by 1.1 mmHg (P < 0.001) at 3 months in eyes with keratoconus after corneal collagen cross-linking (CXL), returning to baseline by ≥4.5 months (P = 0.168).

Growth hormone (GH) therapy was significantly associated with increased intraocular pressure (mean difference [MD] 1.95 mmHg) in children with GH deficiency.

Internal cavities and sub-conjunctival spaces in blebs following minimally invasive bleb surgery (MIBS) were consistently associated with lower intraocular pressure (IOP).

Both anterior and posterior chamber configuration parameters determined based on ultrasound biomicroscopy (UBM) were significantly related to disagreement between gonioscopy and UBM in assessing appositional angle closure in eyes with van Herick grade 2 or less (VH2).

A greater angle-opening distance at 500 μm (P =0.0046) and smaller trabecular ciliary angle (P =0.0158) were related to ultrasound biomicroscopy (UBM) under-diagnosing occludable angles in eyes with van Herick grade 2 or less (VH2).

Longer axial length (P =0.0002), deeper anterior chamber depth (P =0.0121), greater angle-opening distance at 500 μm (P =0.0159), and smaller iris convexity (P =0.0031) were related to ultrasound biomicroscopy (UBM) over-diagnosing occludable angles in eyes with van Herick grade 2 or less (VH2).

In eyes with van Herick grade 2 or less (VH2), ultrasound biomicroscopy (UBM) under-diagnosed occludable angles (i.e., gonioscopy positive, UBM negative) in 12 out of 93 eyes, and UBM over-diagnosed occludable angles (i.e., gonioscopy negative, UBM positive) in 26 out of 93 eyes (McNemar test, P =0.0388).

There was agreement between gonioscopy and ultrasound biomicroscopy (UBM) in diagnosing occludable angles in 37 out of 93 eyes with van Herick grade 2 or less (VH2).

In eyes with van Herick grade 2 or less (VH2), 49 out of 93 eyes were diagnosed as having occludable angles (≥2-ITC GONIO Quad) based on gonioscopy, while 63 out of 93 eyes were diagnosed as having occludable angles (≥2-ITC UBM Quad) based on ultrasound biomicroscopy (UBM).

The investigation proved the noninferiority of Z-HYALCOAT to HEALON EndoCoat in intraocular pressure (IOP) spikes and showed the two devices to be highly similar in all evaluated aspects in a randomized comparative multicenter study of 242 participants undergoing cataract surgery.

The incidence of intraocular pressure (IOP) equal to or higher than 30 mm Hg at 8 hours after device use was 11.2% (13 eyes) in the Z-HYALCOAT investigational group and 17.0% (19 eyes) in the HEALON EndoCoat control group, in a per-protocol population of 242 participants (123 with Z-HYALCOAT and 119 with HEALON EndoCoat) undergoing cataract removal by phacoemulsification and intraocular lens implantation.

Microdrops (MD) dispensed with the Nanodropper adaptor significantly decreased intraocular pressure (IOP) from baseline by 1.6 mm Hg (95% CI 0.88-2.29) in 29 participants with stable primary glaucoma or ocular hypertension on monotherapy, compared with conventional drops (CD) which showed a decrease of 0.13 mm Hg (95% CI -0.26 to 0.52).

The dexamethasone intracanalicular (DEX) insert group and the control group had comparable incidence of intraocular pressure (IOP) elevations ≥10 mm Hg and similar mean IOP changes through postoperative month 1 in a retrospective cohort study of 10,313 DEX+ eyes and 425,098 DEX- eyes undergoing cataract procedures.

At a flow rate of 40 cc/min and an intraocular pressure setpoint of 20 mmHg, the UNITY® Vitreoretinal Cataract System (UVCS) showed a 46% average decrease in occlusion break surge volumes across all vacuum limits compared to the CENTURION® Vision System with Active Sentry™ (CAS) in an eye model representing average human eye compliance.

The CENTURION® Vision System with Active Sentry™ (CAS) had a largest mean surge volume of 75 µL, corresponding to 30% of the average human phakic anterior chamber volume, in an eye model representing average human eye compliance.

The UNITY® Vitreoretinal Cataract System (UVCS) had a largest mean surge volume of 48 µL, corresponding to 19% of the average human phakic anterior chamber volume, in an eye model representing average human eye compliance.

The plungerless intravitreal injector device (IPLID) achieved consistent aqueous humor aspiration (48 ± 5 µL) compared with greater variability using conventional syringe-based aspiration methods (59 ± 17 µL) during anterior chamber paracentesis.