Concept Library

Meta-correlation analysis found a moderate positive correlation between intraocular pressure (IOP) reduction in selective laser trabeculoplasty (SLT)-treated eyes and contralateral eyes at 3-6 months (pooled Pearson's R = 0.65, 95% CI [0.54, 0.73]).

There was no significant difference (p = 0.91) in contralateral intraocular pressure (IOP) reduction between 360° and 180° unilateral selective laser trabeculoplasty (SLT) 3-6 months post-procedure.

Subgroup analysis of unilateral selective laser trabeculoplasty (SLT) demonstrated a mean contralateral intraocular pressure (IOP) reduction of 2.29 mmHg (95% CI [1.30, 3.29]) 3-6 months following 180° SLT.

Subgroup analysis of unilateral selective laser trabeculoplasty (SLT) demonstrated a mean contralateral intraocular pressure (IOP) reduction of 2.21 mmHg (95% CI [1.06, 3.36]) 3-6 months following 360° SLT.

Unilateral selective laser trabeculoplasty (SLT) in primary open-angle glaucoma (POAG) or ocular hypertension (OHT) eyes resulted in a mean contralateral intraocular pressure (IOP) reduction of 1.85 mmHg (95% CI [1.23, 2.47]) 3-6 months after SLT.

The mean number of glaucoma medications decreased from 3.17±1.47 to 2.75±1.70 (P=0.0369) following direct selective laser trabeculoplasty (DSLT) in 12 eyes of 8 phakic patients with primary angle closure glaucoma (PACG) and patent laser peripheral iridotomy (LPI).

Treatment success, defined as an intraocular pressure (IOP) reduction of ≥20% from baseline or a reduction in glaucoma medications while maintaining baseline IOP, was achieved in 7 eyes (58.3%) treated with direct selective laser trabeculoplasty (DSLT) in phakic patients with primary angle closure glaucoma (PACG) and patent laser peripheral iridotomy (LPI).

Direct selective laser trabeculoplasty (DSLT) resulted in an overall mean intraocular pressure (IOP) reduction of 20.3%±11.6% in 12 eyes of 8 phakic patients with primary angle closure glaucoma (PACG) and patent laser peripheral iridotomy (LPI) at the 2-month follow-up.

Direct selective laser trabeculoplasty (DSLT) significantly decreased intraocular pressure (IOP) from a baseline of 17.0±2.3 mm Hg to 13.6±3.0 mm Hg at the 2-month follow-up (P=0.0024) in 12 eyes of 8 phakic patients with primary angle closure glaucoma (PACG) and patent laser peripheral iridotomy (LPI).

This retrospective study, based in a UK NHS centre, found no significant benefit in using prostaglandin analogue (PGA) drops prior to selective laser trabeculoplasty (SLT) compared to SLT as first-line treatment for lowering intraocular pressure (IOP).

Eyes treated with beta-blockers prior to selective laser trabeculoplasty (SLT) showed a greater reduction in intraocular pressure (IOP) compared to other groups.

No significant difference was found in the overall reduction in intraocular pressure (IOP) after selective laser trabeculoplasty (SLT) between eyes treated with prostaglandin analogue (PGA) drops alone prior to SLT (7.89 mmHg, n = 74) and eyes that received SLT as first-line treatment (6.88 mmHg, n = 56).

10 out of 105 eyes that underwent optometrist-performed laser peripheral iridotomy required a redo LPI.

Transient adverse events were reported in 4 out of 105 patients who underwent optometrist-performed laser peripheral iridotomy.

Optometrist two achieved a patent iridotomy in 89% of 105 eyes on which they performed laser peripheral iridotomy.

Optometrist one achieved a patent iridotomy in 93% of 105 eyes on which they performed laser peripheral iridotomy.

Studies on laser trabeculoplasty had lower adherence to World Glaucoma Association (WGA) guidelines (est. = -7.1% [-11%, -3.5%], p < 0.001) compared with trabeculectomy studies in a systematic review of 256 studies.

Most of the Clinical Practice Guidelines for the diagnosis and management of Open Angle Glaucoma (OAG) used the GRADE approach for making recommendations, but showed variability in indications for selective laser trabeculoplasty (SLT) and minimally invasive glaucoma surgery (MIGS).

A subgroup of glaucoma patients had more severe ocular surface disease (OSD) irrespective of the amount of topical glaucoma treatment received, suggesting consideration of laser treatment or non-preserved eye drops for this subgroup.

Aqueous humor MMP activity was significantly increased at 1 day after 1500-mW Micropulse laser trabeculoplasty (MLT) irradiation in pigmented rabbits.

Micropulse laser trabeculoplasty (MLT) at 1500 mW in pigmented rabbits led to significant upregulation of MMP-1, -3, and -9 at day 1, with sustained elevation of MMP-9 at day 7.

Aqueous outflow facility was significantly increased in pigmented rabbits treated with Micropulse laser trabeculoplasty (MLT) at 1000- and 1500-mW.

Micropulse laser trabeculoplasty (MLT) at 1500 mW significantly reduced intraocular pressure (IOP) on days 3 and 7 in pigmented rabbits.

Micropulse laser trabeculoplasty (MLT) at 1000 mW significantly reduced intraocular pressure (IOP) on day 7 in pigmented rabbits.

The ZAP trial investigated the routine use of prophylactic laser peripheral iridotomy, emphasizing the importance of risk stratification in primary angle closure suspects.

The LiGHT trial demonstrated that selective laser therapy is a well tolerated and effective first-line therapy for open-angle glaucoma.

Laser peripheral iridotomy (LPI) in patients with primary angle-closure disease (PACD) (164 eyes: 67 PACS, 54 PAC, 43 PACG) improved lens stability, with the most notable improvement observed in the primary angle-closure glaucoma (PACG) group.

Laser peripheral iridotomy (LPI) in patients with primary angle-closure disease (PACD) (164 eyes: 67 PACS, 54 PAC, 43 PACG) led to a decrease in the differences in iridolenticular angle (ILA) values after LPI in all three groups (PACS: pre-LPI: 9.61 ± 4.76°, post-LPI: 7.27 ± 3.95°; PAC: pre-LPI: 8.96 ± 5.29°, post-LPI: 6.47 ± 3.86°; PACG: pre-LPI: 10.61 ± 6.63°, post-LPI: 6.44 ± 3.77°), with statistically significant differences (P < 0.05).

Laser peripheral iridotomy (LPI) in patients with primary angle-closure disease (PACD) (164 eyes: 67 PACS, 54 PAC, 43 PACG) resulted in an increase in lens position (LP) and relative lens position (RLP) in all three groups, with statistically significant changes (P < 0.05) except for RLP in the PACS group (P > 0.05).

At 5 years, laser peripheral iridotomy (LPI) significantly reduced the risk of persistent gonioscopic angle closure (OR, 0.12 [95% CI, 0.09-0.17]; P < 0.001) in primary angle-closure suspects.

Among 375 phakic participants with 5 years of follow-up, persistent gonioscopic angle closure occurred in 124 laser peripheral iridotomy (LPI)-treated eyes (33.1%) in primary angle-closure suspects.

Utilizing anterior segment optical coherence tomography angiography (AS-OCTA) to guide the laser peripheral iridotomy (LPI) procedure can significantly decrease the incidence of anterior chamber bleeding and mitigate inflammation in patients with primary angle-closure suspect (PACS).

One hour after laser peripheral iridotomy (LPI), the AS-OCTA-guided group showed a larger angle opening distance (AOD750) (P < 0.001) compared with the slit lamp-guided group in 30 patients with primary angle-closure suspect (PACS).

One hour after laser peripheral iridotomy (LPI), the AS-OCTA-guided group showed significantly lower vessel density (P = 0.028), perfusion area (P = 0.003), and anterior chamber particle (ACP) index (P = 0.004) compared with the slit lamp-guided group in 30 patients with primary angle-closure suspect (PACS).

The incidence of anterior chamber bleeding during laser peripheral iridotomy (LPI) was 13.33% in the AS-OCTA-guided group, compared with 43.33% in the slit lamp-guided group (P = 0.010) in 30 patients with primary angle-closure suspect (PACS).

A small laser peripheral iridotomy (LPI) area relative to the pupil area and excessively peripheral LPI locations may be associated with reduced treatment efficacy in patients undergoing LPI for angle-closure.

Anterior chamber volume (ACV) improvement was negatively correlated with the laser peripheral iridotomy (LPI) distance (β=-0.531, p = 0.013) in 29 eyes of 29 patients with angle-closure who underwent LPI.

Negative correlations were found between increases in superior and temporal peripheral anterior chamber depths (ACDs) and the pupil-to-laser peripheral iridotomy (LPI) area ratio (p < 0.05 for all) in 29 eyes of 29 patients with angle-closure who underwent LPI.

Following laser peripheral iridotomy (LPI) in 29 eyes of 29 patients with angle-closure, the mean intraocular pressure decreased significantly from 18.6 ± 4.2 mmHg to 16.6 ± 3.3 mmHg (p < 0.001).

Following laser peripheral iridotomy (LPI) in 29 eyes of 29 patients with angle-closure, central anterior chamber depth (ACD) (1.92 ± 0.21 to 1.91 ± 0.20 mm) remained unchanged (p = 0.432).

Following laser peripheral iridotomy (LPI) in 29 eyes of 29 patients with angle-closure, significant increases were observed in superior (0.93 to 1.00 mm), inferior (1.12 ± 0.20 to 1.26 ± 0.19 mm), temporal (1.23 ± 0.20 to 1.36 ± 0.17 mm), and nasal (1.0 to 1.06 mm) peripheral anterior chamber depths (ACD), anterior chamber volume (ACV) (74.1 ± 13.5 to 84.6 ± 10.8 mm3), and anterior chamber angle (20.4 ± 4.1º to 23.4 ± 4.4º) (p < 0.05, for all).

US glaucoma specialists in private practice, those who completed fellowship training more recently, and those who see more treatment-naive glaucoma patients were significantly more likely to prefer selective laser trabeculoplasty (SLT) over medication.

For advanced primary open angle glaucoma (POAG) on maximum medical therapy, 57% of US glaucoma specialists surveyed favored surgery and 38% preferred selective laser trabeculoplasty (SLT).