Imbalance of Matrix Metalloproteinases and Their Inhibitors Is Correlated With Trabeculectomy Outcomes in Acute Primary Angle Closure.
Qian Tianwei, Fu Mingshui, Hu Chunling, Zhang Zhihua, Xu Xun, Zou Haidong
AI Summary
This study found imbalanced MMP/TIMP ratios in APAC eyes. Lower MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios predict trabeculectomy failure, suggesting potential targets for improving surgical outcomes.
Abstract
Purpose
To analyze matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and their molar ratios in the aqueous humor in previous acute primary angle closure (APAC) patients and their correlations with trabeculectomy outcomes.
Design
Prospective cohort study.
Methods
Aqueous humor samples were collected from a total of 78 eyes, including 52 previous APAC eyes and 26 cataract eyes. TIMP-1, 2, 3, and 4 and MMP-1, 2, 3, 7, 8, 9, 12, and 13 analyte concentrations were measured using multiplexed immunoassay kits. Patient follow-up occurred at 1 week and 1, 3, 6, 12, and 18 months.
Results
In the previous APAC group, 11 MMP/TIMP molar ratios were significantly lower. APAC eyes were then followed for up to 18 months after trabeculectomy and divided into success (37 eyes) and failure (15 eyes) groups. Five out of the 11 molar ratios were significantly lower in the failure group than in the success group. In multiple logistic regression analysis, failed filtration surgery was more likely in APAC eyes with lower MMP-2/TIMP-2 (P = .040, odds ratio = 44.499) and MMP-13/TIMP-1 (P = .034, odds ratio = 37.947) ratios. Previous APAC eyes were divided according to MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios. Compared to eyes with high ratios, eyes with low MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios had significantly higher failure rates.
Conclusions
In previous APAC eyes, changes in MMP and TIMP levels resulted in MMP and TIMP imbalance. Lower MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios in aqueous humor are risk factors for trabeculectomy failure. Modulating specific MMP/TIMP ratios may have potential clinical applications for filtration surgery.
MeSH Terms
Shields Classification
Key Concepts5
Failed filtration surgery was more likely in previous acute primary angle closure (APAC) eyes with lower MMP-2/TIMP-2 ratios (P = .040, odds ratio = 44.499) and lower MMP-13/TIMP-1 ratios (P = .034, odds ratio = 37.947) in aqueous humor, as determined by multiple logistic regression analysis.
Previous acute primary angle closure (APAC) eyes with low MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios had significantly higher trabeculectomy failure rates compared to eyes with high ratios.
Lower MMP-2/TIMP-2 and MMP-13/TIMP-1 ratios in aqueous humor are risk factors for trabeculectomy failure in previous acute primary angle closure (APAC) eyes.
In previous acute primary angle closure (APAC) eyes, 11 matrix metalloproteinase (MMP)/tissue inhibitors of metalloproteinases (TIMP) molar ratios were significantly lower compared to cataract eyes.
Five out of 11 MMP/TIMP molar ratios were significantly lower in the trabeculectomy failure group (15 eyes) compared to the success group (37 eyes) in previous acute primary angle closure (APAC) eyes followed for up to 18 months after trabeculectomy.
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